Research on Excessive Iodine Status in Pregnancy

Pregnancy Related Clinical Trial

Official title: A Prospective Observational Study on Health Effect of Excessive Iodine Exposure in Pregnancy

Status Completed

Clinical Trial Summary

To explore main cause and health impact of iodine excess during pregnancy, we performed iodine evaluation for 390 consecutive pregnant women from January 1st, 2016 to December 31st, 2016. Among them, 18 women (4.62%) with apparently elevated urinary iodine concentration (UIC) were enrolled onto this study for subsequent follow-up. History of high iodine exposure was collected from all participants. Parameters about iodine status were monitors until termination of pregnancy, and dietary iodine intake condition and thyroid function were also evaluated.

Clinical Trial Description

A prospective follow-up was arranged for the 18 pregnant women with excessive iodine status. History of iodine exposure (including hysterosalpingography (HSG) using an oil-soluble iodinated contrast medium, examination by computed tomography scan with contrast, administration of amiodarone, history of receiving radioiodine therapy, etc.) was collected from all participants. Evaluation of dietary iodine intake was performed through a 72-hour dietary recall.The serum iodine concentration (SIC) and urinary iodine concentration (UIC) were monitored continuously in the whole course of pregnancy. All subjects with excessive iodine load were recommended by nutritionists to have their dietary iodine intake restricted, and resume iodine-containing supplements and foods until the UIC＜250 μg/L and SIC≤90 μg/L. After delivery, maternal colostrum iodine concentration and neonatal iodine status (including neonatal UIC, condition of congenital hypothyroidism screening tests, and thyroid physical examination) were also assessed. ;

Related Conditions & MeSH terms

• Excessive Iodine Status
• Infant, Newborn, Diseases
• Neonatal Disorder
• Pregnancy Related
• Thyroid Dysfunction, Antepartum

• NCT number: NCT03422406
• Study type: Observational
• Source: Peking Union Medical College Hospital
• Status: Completed
• Phase: N/A
• Start date: January 2016
• Completion date: March 2017