Pregnancy Complications Clinical Trial
Official title:
Cytomegalovirus Infection and Pregnancy Outcomes
The purpose of this study is to determine if (recurrent) cytomegalovirus (CMV) infection of the mother results in pregnancy complications such as preterm delivery, severe preeclampsia, poor fetal growth, or stillbirth.
CMV infection in adults with a normal immune system is rarely a serious event. Once a person
has been infected with CMV, they may have recurrences (relapses) of the infection. If a
mother is infected with the virus or relapses during pregnancy, her fetus may be at risk for
infection. Unlike infection in adults, fetal infection may result in serious complications
(congenital infection). The effects of fetal infection with CMV are well understood and many
efforts have been made to potentially reduce the risk of congenital infection. However, the
effect of CMV infection on the pregnancy itself (when the fetus is not affected by CMV) is
less understood.
In this study, we plan to determine if CMV recurrence in the mother results in pregnancy
complications. The pregnancy complications listed above have been associated with poor
placental function. We also plan to determine if (recurrent) CMV infection in the mother is
associated with CMV infection of the placenta.
;
Observational Model: Case-Only
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