Preeclampsia Clinical Trial
Official title:
The Expression of Aquaporin 3, 8 and 9 in Placenta, Umbilical Cord and Fetal Membranes in Normal Pregnancies and Pregnancies Complicated by Preeclampsia: Perinatal and Neonatal Outcomes.
The etiologic agent responsible for the development of preeclampsia remains unknown.
Aquaporins, members of integral membrane proteins, are responsible of water molecules
movements through the plasma membrane channels, energy metabolism and associated with
changes in cellular volume during apoptosis.
İn such placental pathology as preeclampsia, characterized with superficial implantation and
increased apoptosis leading to a relative hypoxia between mother and fetus, the hypothesis
of aquaporins important role in energy homeostasis and apoptosis maybe suggested.
The investigators are carrying out a study of 210 pregnant women , from whom 105 will have
pregnancy complicated with preeclampsia and 105 with normal pregnancy.
The investigators aim is to investigate the role of the placenta, umbilical cord and
amniotic membrane aquaporin expression in etiopathogenesis of preeclampsia. The
investigators will compare aquaporin levels in preeclamptic and normal placentas, umbilical
cords and amniotic membranes , and investigate relation between aquaporin levels and
perinatal ( maternal blood pressure, proteinuria, maternal-fetal doppler ultrasound,
amniotic fluid index, fetal intrauterine growth) and neonatal ( Apgar score, biometry,
complications) finding.
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Observational Model: Case Control, Time Perspective: Prospective
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