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Metformin and Systemic Inflammation in HIV — Metfo  

PreDiabetes Clinical Trial

Official title:
Metformin Administration Effect Over Systemic Inflammation Serum Markers in HIV Positive Prediabetic Patients

Clinical Trial Summary

The purposes of this study are to find out if: metformin can be combined with anti-HIV drugs to reduce systemic inflammation measured by the determination of cytokines and other series of serum markers. To determine if the concomitant administration of metformin with TARA improves the immune function on the CD4 T cell count and its relation with the CD8 T cells, during the treatment and after its interruption.

To this end, in the present study, patients with prediabetes (who meet the fasting impaired glucose criteria) will be identified and treated with metformin or placebo for 8 weeks, receiving stable TARA and with a CD4 + level> 200 cells / μL.

40 patients from the HIV Unit of the Civil Hospital of Guadalajara "Fray Antonio Alcalde" will be included in this study and the intervention will last 8 weeks.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03774108
Study type Interventional
Source Hospital Civil de Guadalajara
Contact
Status Active, not recruiting
Phase Phase 4
Start date December 15, 2018
Completion date January 8, 2020
View Details
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