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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT06329284
Other study ID # RC 31.1.2024
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date January 1, 2023
Est. completion date December 15, 2023

Study information

Verified date March 2024
Source Benha University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Preeclampsia (PE) is a hypertensive pregnancy-related disorder that endangers maternal and fetal outcomes and accounts for 9-10% of maternal mortalities with its early-onset phenotype is the most dangerous, but its etiology is still not fully elucidated. Midkine (MDK) is a multifunctional protein that plays a unique role in the development of hypertension (HTN), via its proatherogenic effect and induction of overexpression of angiotensin converting enzyme. Oxidative stress (OS) upregulates the expression of MDK and MDK induces propagation of neoangiogenesis and acts as chemotactic for neutrophils.


Recruitment information / eligibility

Status Completed
Enrollment 80
Est. completion date December 15, 2023
Est. primary completion date September 15, 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 21 Years to 50 Years
Eligibility Inclusion Criteria: - Newly pregnant normotensive (NT) women with singleton fetus; - Free of the Exclusion Criteria. Exclusion Criteria: - Women with history of complicated pregnancy; - Had manifest essential hypertension, Diabetes Mellitus or chronic kidney diseases; - Had multiple gestational sacs, morbid obesity with Body Mass Index at time of pregnancy diagnosis over 35 kg/m2; - Had genetic disorders, coagulopathy, autoimmune diseases or maintained on immunosuppressive therapy.

Study Design


Related Conditions & MeSH terms


Intervention

Diagnostic Test:
ELISA
ELISA estimation of serum Midkine, tumor necrosis factor Alfa, superoxide dismutase, malondialdehyde, placental growth factor and placental soluble fms-like tyrosine kinase 1

Locations

Country Name City State
Egypt Banha University Banha El- Qalyobia

Sponsors (1)

Lead Sponsor Collaborator
Benha University

Country where clinical trial is conducted

Egypt, 

Outcome

Type Measure Description Time frame Safety issue
Primary Severity of Pre-Eclampsia (PE) Correlation between Serum midkine levels and blood pressure measurements 8 months
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