Posttraumatic Stress Disorders Clinical Trial
Official title:
The Use of Propranolol to Block Memory Reconsolidation in Post Traumatic Stress Disorders (PTSD)
Verified date | October 2016 |
Source | Wayne State University |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Interventional |
The purpose of this investigation is to see if propranolol will reduce the psychophysiological hyperactivation associated with memories of combat stress in Veterans with Posttraumatic Stress Disorder.
Status | Terminated |
Enrollment | 12 |
Est. completion date | September 2015 |
Est. primary completion date | August 2015 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 45 Years |
Eligibility |
Inclusion Criteria: - Participants will meet the clinical criteria of PTSD (DSM IVTR) secondary to combat exposure. Exclusion Criteria: - Current illicit substance use or alcohol consumption, as determined by urine toxicology and alcohol breath test. - Any diagnosis of current comorbid psychotic disorders, bipolar disorder, or illicit substance or alcohol abuse or dependence. - Any current prescription medication usage or supplement (dietary or herbal) usage that is contraindicated with propranolol. - Active enrollment into any psychiatric or psychological treatment. - Any condition that contraindicates the use of propranolol, such as: - history of bronchial asthma. - heart block. - sinus bradycardia. - congestive heart failure. - insulin-dependent diabetes. - initial systolic blood pressure < 100 mmHg. - Hyperthyroidism. - Thyroid disease. - Renal or liver impairment. |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | John D Dingell VA Hospital | Detroit | Michigan |
Lead Sponsor | Collaborator |
---|---|
Wayne State University | John D. Dingell VA Medical Center, New York University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Facial corrugator EMG | Change in Facial corrugator EMG from baseline at 1 month post-intervention | No | |
Secondary | CAPS score | Change in CAPS score from baseline at 1 month post-intervention | No | |
Secondary | PCL-M score | Change in PCL-M score from baseline at 1 month post-intervention | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02057081 -
Multifamily Group to Reduce Marital Conflict and Disability in Veterans With mTBI
|
N/A | |
Completed |
NCT03684473 -
An Online CBT, Mindfulness Meditation & Yoga (CBT-MY) Intervention for Posttraumatic Stress Disorder
|
N/A | |
Active, not recruiting |
NCT00965809 -
Add on Study on Δ9-THC Treatment for Posttraumatic Stress Disorders (PTSD)
|
Phase 4 | |
Unknown status |
NCT01033708 -
A Randomized Control Trial of Narrative Exposure Therapy Versus Treatment as Usual in the Therapy of Borderline Personality Disorder
|
N/A | |
Completed |
NCT02774642 -
Integrated CBT-I and PE on Sleep and PTSD Outcomes (Impact Study)
|
N/A | |
Completed |
NCT01049516 -
Prolonged Exposure for Post Traumatic Stress Disorder (PTSD) Among Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) Personnel
|
N/A | |
Completed |
NCT00105885 -
Telephone Care as a Substitute for Routine Psychiatric Medication
|
N/A | |
Completed |
NCT02556645 -
A Comparison of Web-Prolonged Exposure (Web-PE) and Present-Centered Therapy (PCT) for PTSD Among Active-Duty Military Personnel
|
N/A | |
Recruiting |
NCT01743664 -
The Efficacy of EMDR in Patients With PTSD in Multiple Sclerosis
|
Phase 3 | |
Completed |
NCT01158001 -
Telemedicine for Improved Delivery of Psychosocial Treatments for Post Traumatic Stress Disorder
|
N/A | |
Completed |
NCT03997344 -
Veterans Nature Therapy (Vet Hike)
|
N/A | |
Completed |
NCT01605253 -
Eszopiclone for the Treatment of Posttraumatic Stress Disorder
|
Phase 4 | |
Not yet recruiting |
NCT02384369 -
Trial of Oral SNC-102 in Subjects With Combat-Related Posttraumatic Stress Disorder
|
Phase 2 | |
Enrolling by invitation |
NCT02757339 -
Evaluating the Neurobiological Basis of Traumatic Dissociation in Women With Histories of Abuse and Neglect
|
||
Active, not recruiting |
NCT01157416 -
Effect of D-cycloserine on Treatment of Posttraumatic Stress Disorder (PTSD) in Youth
|
Phase 2 | |
Completed |
NCT01208844 -
Study of Physical Health for Women With Posttraumatic Stress or Depression
|
N/A | |
Not yet recruiting |
NCT01914861 -
Cortisol Diurnal Variation and the Risk for Developing Post Traumatic Stress Disorder
|
N/A | |
Unknown status |
NCT01644851 -
Cognitive Training for Post Traumatic Stress Disorder: Effects on Cognitive, Emotional, and Brain Function
|
N/A | |
Completed |
NCT01896388 -
Ifenprodil Tartrate Treatment of Adolescents With Post-traumatic Stress Disorder: a Double-blind, Placebo-controlled Trial
|
Phase 1/Phase 2 | |
Recruiting |
NCT01947725 -
Behavioral Activation for Smoking Cessation in Veterans With PTSD
|
N/A |