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Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms — MAGNETS  

Posttraumatic Stress Disorder Clinical Trial

Official title:
Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms

Clinical Trial Summary

MAGNETS is a prospective, randomized, parallel-design, sham-controlled clinical trial of accelerated, functional magnetic resonance imaging (fMRI)-guided intermittent theta burst stimulation (iTBS) to the right dorsolateral prefrontal cortex (dlPFC) for chronic symptoms of posttraumatic stress disorder (PTSD) in a comorbid Veteran population.

Clinical Trial Description

In MAGNETS, sixty-four participants will be recruited from the NMVAHCS PTSD programs, Polytrauma services, and outpatient mental health clinics. At study entry (Visit #1), participants will undergo baseline demographic, behavioral, and cognitive assessment, and fMRI and diffusion tensor imaging (DTI). The data analysis team will then determine the image-based target in the right hemisphere. Participants will be randomized to either the active (n=32) or sham (n=32) group and undergo 50 sessions of iTBS (10x/day, five days). At end of treatment (Visit #2), they will repeat all baseline tests, including fMRI. One-, three- and six-month symptom levels will be obtained through phone visits (Visits #3-5) to establish longevity and stability of benefit. Repeated measures analyses will be performed on behavioral and connectivity variables, with clinical (age, duration, head injury history) and imaging (white matter fiber counts) features as covariates. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06449326
Study type Interventional
Source University of New Mexico
Contact Davin Quinn, MD
Phone 505-272-9494
Email dquinn@salud.unm.edu
Status Not yet recruiting
Phase N/A
Start date June 1, 2024
Completion date October 1, 2027
View Details
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