Posttraumatic Stress Disorder Clinical Trial
— MARIOfficial title:
A Randomized Controlled Trial of the Mobile Anger Reduction Intervention for Veterans
Difficulty controlling anger is the most commonly reported reintegration concern among combat Veterans, especially those with a diagnosis of posttraumatic stress disorder (PTSD). Problematic anger is associated with significant functional impairment. In the current project, the investigators will compare the Mobile Anger Reduction Intervention (MARI) with a health education mobile intervention (HED) among Veterans with PTSD and problematic anger. Participants will be randomized to the MARI or HED condition. The hypothesis is that participants in the MARI condition will experience greater anger reductions and functional improvements relative to the HED condition.
Status | Not yet recruiting |
Enrollment | 150 |
Est. completion date | March 31, 2028 |
Est. primary completion date | September 30, 2027 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - Veterans diagnosed with PTSD, established via chart review and a score of greater than or equal to 33 on the PTSD Checklist for DSM-5 (PCL-5) - Reporting a score of greater than or equal to 12 on the 5-item Dimensions of Anger Reactions Scale - Have not had any changes to type or dose of psychiatric medications for 3 months, with no plans to make adjustments in the next 6 months - Able to read at least 6th grade level material Exclusion Criteria: - Currently in a period of active psychosis or mania - Exhibit current prominent suicidal or homicidal ideation requiring immediate intervention - Have used the MARI application before as part of another research study - Receiving (or plan to receive) other anger management psychotherapy or trauma-focused therapy for PTSD (i.e., prolonged exposure, cognitive processing therapy during the course of the study |
Country | Name | City | State |
---|---|---|---|
United States | Durham VA Medical Center, Durham, NC | Durham | North Carolina |
Lead Sponsor | Collaborator |
---|---|
VA Office of Research and Development |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | number of participants below the clinical cut off for problematic anger | Measured with the Dimensions of Anger Reactions-5 scale; scores range from 5-25, with higher scores indicating higher levels of problematic anger; the clinical cut off is 12. We will count the number of participants in each group who have a score lower than 12. | Post-treatment (approx. one month after baseline assessment) | |
Primary | number of participants below the clinical cut off for problematic anger | Measured with the Dimensions of Anger Reactions-5 scale; scores range from 5-25, with higher scores indicating higher levels of problematic anger; the clinical cut off is 12. We will count the number of participants in each group who have a score lower than 12. | 6-month follow-up | |
Primary | number of participants below the clinical cut off for problematic anger | Measured with the Dimensions of Anger Reactions-5 scale; scores range from 5-25, with higher scores indicating higher levels of problematic anger; the clinical cut off is 12. We will count the number of participants in each group who have a score lower than 12. | 3-month follow-up | |
Primary | number of participants with decreased hostile interpretation bias scores | Measured with the Word Sentence Association Paradigm-Hostility, hostility subscale. Scores range from 1-6, with higher scores indicating higher levels hostile interpretation bias. We will count the number of participants in each group who have a reduction in scores within the time frame. | from baseline to post-treatment assessments (approx. one month after baseline assessment) | |
Primary | number of participants with decreased hostile interpretation bias scores | Measured with the Word Sentence Association Paradigm-Hostility, hostility subscale. Scores range from 1-6, with higher scores indicating higher levels hostile interpretation bias. We will count the number of participants in each group who have a reduction in scores within the time frame. | from baseline to 3-month follow-up | |
Primary | number of participants with decreased hostile interpretation bias scores | Measured with the Word Sentence Association Paradigm-Hostility, hostility subscale. Scores range from 1-6, with higher scores indicating higher levels hostile interpretation bias. We will count the number of participants in each group who have a reduction in scores within the time frame. | from baseline to 6-month follow-up | |
Secondary | number of participants with decreased psychosocial impairment scores | Measured with the Brief Inventory of Psychosocial Functioning. Scores range from 0-6, with higher scores indicating higher levels of psychosocial impairment. We will count the number of participants in each group who have a reduction of scores within the time frame. | from baseline to post-treatment assessments (approx. one month after baseline assessment) | |
Secondary | number of participants with decreased psychosocial impairment scores | Measured with the Brief Inventory of Psychosocial Functioning. Scores range from 0-6, with higher scores indicating higher levels of psychosocial impairment. We will count the number of participants in each group who have a reduction of scores within the time frame. | from baseline to 3-month follow-up | |
Secondary | number of participants with decreased psychosocial impairment scores | Measured with the Brief Inventory of Psychosocial Functioning. Scores range from 0-6, with higher scores indicating higher levels of psychosocial impairment. We will count the number of participants in each group who have a reduction of scores within the time frame. | from baseline to 6-month follow-up | |
Secondary | number of participants with improved quality of life | Measured with the Quality of Life Inventory. Scores range from -6-6, with higher scores indicating higher levels of satisfaction with life. We will count the number of participants in each group who have an increase in their score within the time frame. | from baseline to post-treatment assessments (approx. one month after baseline assessment) | |
Secondary | number of participants with improved quality of life | Measured with the Quality of Life Inventory. Scores range from -6-6, with higher scores indicating higher levels of satisfaction with life. We will count the number of participants in each group who have an increase in their score within the time frame. | from baseline to 3-month follow-up | |
Secondary | number of participants with improved quality of life | Measured with the Quality of Life Inventory. Scores range from -6-6, with higher scores indicating higher levels of satisfaction with life. We will count the number of participants in each group who have an increase in their score within the time frame. | from baseline to 6-month follow-up | |
Secondary | number of participants with reduced suicidal ideation | Measured with the Columbia- Suicide Severity Rating Scale, suicidal ideation intensity rating. Scores range from 0-25, with higher scores indicating higher intensity of suicidal ideation. We will count the number of participants in each group who have a decrease in their score within the time frame. | from baseline to post-treatment assessments (approx. one month after baseline assessment) | |
Secondary | number of participants with reduced suicidal ideation | Measured with the Columbia- Suicide Severity Rating Scale, suicidal ideation intensity rating. Scores range from 0-25, with higher scores indicating higher intensity of suicidal ideation. We will count the number of participants in each group who have a decrease in their score within the time frame. | from baseline to 3-month follow-up | |
Secondary | number of participants with reduced suicidal ideation | Measured with the Columbia- Suicide Severity Rating Scale, suicidal ideation intensity rating. Scores range from 0-25, with higher scores indicating higher intensity of suicidal ideation. We will count the number of participants in each group who have a decrease in their score within the time frame. | from baseline to 6-month follow-up |
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