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Trial of Mifepristone in Combat Veterans With Posttraumatic Stress Disorder

Posttraumatic Stress Disorder Clinical Trial

Official title:
Novel Therapeutics in PTSD: A Randomized Clinical Trial of Mifepristone

Clinical Trial Summary

The investigators propose to conduct a randomized double-blind, parallel-group, placebo-controlled trial of mifepristone in veterans with military-related posttraumatic stress disorder (PTSD). This study will examine the clinical, neuropsychological, and neuroendocrine effects of short-term treatment of mifepristone (600 mg/day for one week) to determine if this treatment is efficacious in improving PTSD symptoms, cognitive functioning, or other related clinical measures. Additionally, the investigators will observe whether baseline neuroendocrine activity, or other clinical or neuropsychological factors predict the response to mifepristone, and whether mifepristone-induced changes in neuroendocrine activity are associated with treatment outcome.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor)

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00833339
Study type Interventional
Source James J. Peters Veterans Affairs Medical Center
Contact Julia A. Golier, M.D.
Phone 718-584-9000
Email julia.golier@va.gov
Status Recruiting
Phase Phase 2
Start date May 2008
Completion date October 2015
View Details
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