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Postsurgical Pain clinical trials

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NCT ID: NCT06412380 Completed - Postoperative Pain Clinical Trials

Influence of Insertion Torque and Bone Type on Post-operative Pain

Start date: December 1, 2019
Phase: N/A
Study type: Interventional

The objectives of this clinical study were to assess the effect of different ITs and bone types on POP levels and survival rates and to investigate the effect of different patient- and site-related factors on POP levels and survival rates.

NCT ID: NCT05607641 Completed - Postsurgical Pain Clinical Trials

Efficacy and Safety Study of Ketorolac / Pitofenone / Fenpiverinium for the Treatment of Patients With Pain After Surgical Abdominal and Pelvic Operations

Start date: July 7, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

Neospastil (ketorolac tromethamine / pitofenone hydrochloride / fenpiverinium bromide fixed-dose combination) in a form of solution for injections and film-coated tablets has been studied as a treatment for pain after surgical abdominal and pelvic operations. The aim of the study was to test the hypothesis that Neospastil was non-inferior (phase II) and superior (phase III) than ketorolac tromethamine monotherapy due to the additional relaxing effect of pitofenone and fenpiverinium on the smooth muscles of internal organs. The study also aimed to show that Neospastil is safe and well-tolerated in people who have pain after surgical abdominal and pelvic operations. Study treatment was initiated with parenteral form of study drug (first 24 hours) and then switched to oral formulation. This trial was conducted in accordance with the ethical principles of Good Clinical Practice and International Council for Harmonization (ICH) Harmonized Tripartite Guidelines.

NCT ID: NCT04774328 Completed - Postsurgical Pain Clinical Trials

Preliminary Study of CA-008 (Vocacapsaicin) in Patients Undergoing Ventral Hernia Repair

Start date: September 9, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

A Three-Part, Phase 1/2, Randomized, Double-blind, Placebo-Controlled, Adaptive Safety, Pharmacokinetics, and Preliminary Efficacy Study of CA-008 (Vocacapsaicin) in Patients Undergoing Ventral Hernia Repair

NCT ID: NCT04648683 Completed - Opioid Use Clinical Trials

Postoperative Telehealth Mindfulness Intervention After Spine Surgery

Start date: December 21, 2021
Phase: N/A
Study type: Interventional

Lumbar spine pain is the leading cause of years lived with a disability and affects over 50 million individuals in the United States. Rates of spine surgeries performed to address degenerative spine conditions have increased markedly. A subset of patients experience poor pain, functional, or quality of life outcomes after surgery. This study will adapt and evaluate the feasibility and potential benefits of both a one-on-one and a group-delivered, face-to-face telehealth, mindfulness intervention for patients recovering from lumbar spine surgery. The goals of the intervention are to improve short and long-term pain management, reduce the need for long-term pain medications, and improve physical and psychological well-being after surgery. The study will result in a refined intervention manual based on feasibility, participant exit interviews and satisfaction surveys which will be piloted in a future randomized controlled trial.

NCT ID: NCT04203537 Completed - Postsurgical Pain Clinical Trials

Study Evaluating the Safety, Efficacy and Pharmacokinetics of CA-008 (Vocacapsaicin)

Start date: December 4, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

In the pilot (Part A) of this study, multiple doses of CA-008 (vocacapsaicin) were evaluated for safety, tolerability, and PK. Doses were then selected for the expanded part (Part B) of the study, where CA-008 was compared to placebo. Patients had serial assessments of safety, PK, and drug effect.

NCT ID: NCT03789318 Completed - Postsurgical Pain Clinical Trials

Study in Subjects Undergoing Complete Abdominoplasty

Start date: December 3, 2018
Phase: Phase 2
Study type: Interventional

Phase 2, single center, randomized, double-blind, placebo-controlled, parallel design study of CA-008 vs. placebo in subjects undergoing an elective C-ABD under general anesthesia supplemented with a bupivacaine hydrochloride (HCl)transverse abdominis plane (TAP) block.

NCT ID: NCT03731364 Completed - Postsurgical Pain Clinical Trials

Study of CA-008 (Vocacapsaicin) in Total Knee Arthroplasty

Start date: October 29, 2018
Phase: Phase 2
Study type: Interventional

This is a two-part, Phase 2, multi-center, randomized, double-blind, placebo-controlled, parallel design study of CA-008 (vocacapsaicin) vs. placebo injected/instilled during an elective TKA.

NCT ID: NCT02081703 Completed - Postsurgical Pain Clinical Trials

Study to Evaluate Safety/Efficacy of a Single Pre-Op Dose of AYX1 Injection to Treat Pain After Knee Replacement Surgery

Start date: May 2014
Phase: Phase 2
Study type: Interventional

The objectives of this study are to evaluate the safety and analgesic efficacy of a single preoperative intrathecal administration of AYX1 Injection at two dose/volume levels.

NCT ID: NCT01731730 Completed - Postsurgical Pain Clinical Trials

Study to Evaluate Safety/Efficacy of a Single Pre-Op Dose of AYX1 Injection to Treat Pain After Knee Replacement Surgery

Start date: January 2013
Phase: Phase 2
Study type: Interventional

The objectives of this proof of concept study are to evaluate the safety and preventive analgesic efficacy of a single preoperative intrathecal administration of AYX1 Injection in patients undergoing unilateral total knee arthroplasty.

NCT ID: NCT01582477 Completed - Analgesia Clinical Trials

TAP-patients With Robotic Assisted Lap Prostatectomy

TAP
Start date: March 2012
Phase: Phase 4
Study type: Interventional

The purpose of the study is to assess the safety and efficacy of EXPAREL when administered via infiltration into the transversus abdominis plane (TAP) to prolonged postsurgical analgesia in men undergoing robot-assisted laparoscopic prostatectomy.