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Clinical Trial Summary

Postpolypectomy bleeding is the most common major complication following a colonoscopic polypectomy procedure. The incidence rate ranging from 0.3 to 6.1%. Several preventive methods such as detachable snare and adrenaline injection have been proposed in the management of postpolypectomy bleeding in large colonic polyps. It has been demonstrated that administration of ascorbic acid (vitamin C) in abdominal surgeries could reduce the blood loss during the procedure, operation time and days of hospitalization. So the investigators designed a prospective, randomized study to compares the efficacy of vitamin C administration with application of prophylactic clip and detachable snare in the prevention of postpolypectomy bleeding in large polyps.


Clinical Trial Description

In this prospective, randomized clinical trial, patients diagnosed with colon polyps with a diameter > 10 mm will randomized to receive either a 500 mg vitamin C in normal saline injection or a normal saline injection 2 hours before polypectomy. This administration will continued for 3 days after polypectomoy. Postpolypectomy bleeding is defined either as (1) early: occurring either during an endoscopic procedure or immediately after as hematochezia within 24 h or (2) delayed: any bleeding event that occurring between day 2 and day 30 following the polypectomy procedure. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03374410
Study type Interventional
Source Shahid Beheshti University
Contact
Status Withdrawn
Phase N/A
Start date December 20, 2017
Completion date July 30, 2018

See also
  Status Clinical Trial Phase
Terminated NCT01565993 - The Use of Prophylactic Hemoclips in the Endoscopic Resection of Large Pedunculated Polyps N/A
Completed NCT03400020 - Efficacy of Vitamin C Administration for the Prevention of Postpolypectomy Bleeding N/A
Completed NCT02036047 - The Effectiveness of an Exclusive Cold Snare Polypectomy Snare for the Removal of Diminutive Colorectal Polyps N/A