Efficacy Of Ultrasound Guided External Oblique Intercostal Plane Block for Subcostal Nephrectomy

Postoperative Pain Clinical Trial

— EOINB  

Official title:

Efficacy Of Ultrasound Guided External Oblique Intercostal Plane Block for Postoperative Analgesia in Patients Undergoing Subcostal Nephrectomy: A Randomised Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06056479
• Other study ID #: 9/2023ANET1-1
• Status: Completed
• Phase: N/A
• Start date: September 1, 2023
• Est. completion date: February 25, 2024

Study information

• Verified date: March 2024
• Source: Menoufia University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The patients will be randomly allocated into two equal groups using a computer program.

Group A: will receive external oblique intercostal block after induction. Group B: will receive postoperative morphine per patient request.

Description:

General anaesthesia induction will be achieved using fentanyl 1µg/kg (IV), propofol 2mg/kg (IV), and0.5mg/kg of IV Atracurium. General anaesthesia will be maintained with mechanical ventilation with isoflurane with O2 \ Air mixture.

During anaesthesia maintenance Intraoperatively, if BP or heart rate (HR) increase more than 20% from baseline, intravenous morphine will be given to stabilize the patients' haemodynamics.

All patients will receive 1g intravenous paracetamol and 4mg ondansetron 8mg dexamethasone.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: February 25, 2024
• Est. primary completion date: February 10, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Eligible patients will be older than 18 years old with American society of anestheologist ASA physical status I, II and III scheduled for Trans-Abdominal ( Anterior Subcostal) Nephrectomy

Exclusion Criteria:

• Patients who are:

• Unable to cooperate.

• Patients who have allergy to any of the study drugs.

• Patients who are on opioids.

• Known abuse of alcohol or medication.

• Local infection at the site of injection or systemic infection.

• Pregnancy

• Patients with coagulation disorders or on anticoagulation therapy

Related Conditions & MeSH terms

• Pain, Postoperative
• Postoperative Pain

Intervention

Procedure:
• external oblique intercostal block
20 ml of bupivacaine 0.25% will be administered by US into external oblique intercostal plane at the level of sixth rib space .

Locations

Country	Name	City	State
Egypt	Menoufia university	Cairo	Shibin Elkom

Sponsors (1)

Lead Sponsor	Collaborator
Menoufia University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Time for first rescue analgesia	hours	day 0
Secondary	VAS score	1 to 10 (0 is interpreted as no pain, 1-4 mild pain, 5-6 moderate pain, 7-10 severe pain)	24 hours
Secondary	rescue analgesics	morphine mg	24hous