Postoperative Pain Clinical Trial
Official title:
Role of Co-administered Dexmedetomidine Or Clonidine With Bupivacaine for Transversus Abdominis Plane Block in Patients Undergoing Elective Caesarean Section: A Randomized, Double-blind Controlled Trial
Aim to study the efficacy of co-administered Dexmedetomidine Or Clonidine with Bupivacaine
and that of bupivacaine 0.25% alone for Transversus Abdominis Plane (TAP) Block for
Postoperative Analgesia in Patients Undergoing Elective Caesarean Section.
- Group 1: bupivacaine 0.25% + Dexmedetomidine 0.5 mcg/kg (a total volume of 40 ml (20 ml
each side) was used for the TAP block.)
- Group 2: 20 ml bupivacaine+1ug/kg clonidine bilaterally (a total volume of 40 ml (20 ml
each side) was used for the TAP
- Group3: bupivacaine 0.25% + placebo (a total volume of 40 ml (20 ml each side) was used
for the TAP A prospective Randomized Interventional double-blind study.
Women, following Caesarean delivery, have even more compelling reasons to receive optimal post-operative pain relief, for improved maternal and neonatal well-being. Also, adequate pain relief helps the patient to ambulate early and prevent any thrombotic incidents . Dexmedetomidine, an imidazole compound, is the pharmacologically active dextroisomer of medetomidine that displays specific and selective α 2-adrenoceptor agonist activity and causes sedation, analgesia without any delirium, or respiratory depression. The mechanism of action is unique and differs from those of currently used agents, including clonidine. ;
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