Postoperative Pain Clinical Trial
Official title:
Effect of Magnesium Sulfate When Added to TAP Block With Bupivacaine in Patients Undergoing Laparoscopic Cholecystectomy.
Ultrasound-guided transversus abdominis plane block is now widely used in abdominal surgery. Recently, magnesium sulphate is used as adjuvant to local anesthetics.
A significant pain experienced by patients after laparoscopic cholecystectomy surgery is
required so as to block nociceptive transmission from both the abdominal wall incision, and
visceral sites.
Using of opioids can result in significant adverse effects, thus delaying early mobilization
of patients.
Ultrasound-guided transversus abdominis plane (TAP) block has been used as a satisfactory
approach that provides postoperative analgesia. TAP block is safe; it diminishes or replaces
the use of opioids; and it has a lower incidence of adverse effects.
Bupivacaine is a medication used to decrease feeling in a specific area. It is used by
injecting it into the area, around a nerve that supplies the area, or into the spinal canal's
epidural space. Bupivacaine is indicated for local infiltration, peripheral nerve block,
sympathetic nerve block, and epidural and caudal blocks.
Magnesium is the fourth most plentiful cation in our body. It may be worthwhile to further
study the role of supplemental magnesium in providing perioperative analgesia, because this
is a relatively harmless molecule, is not expensive and also because the biological basis for
its potential antinociceptive effect is promising.
Magnesium sulphate (MgSO4), N-methyl-D-aspartate receptor antagonist has the potential to be
an ideal adjuvant in TAP block.
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