Postoperative Pain Clinical Trial
Official title:
Opioid Free Anesthesia in Bariatric Surgery: A Prospective, Double-blinded, Randomized, Controlled Clinical Trial
This study compares the intraoperative opioid free anesthesia approach in laparoscopic bariatric surgery to a conventional opioid- based anesthesia. Half of participants will receive opioid free anesthesia with dexmedetomidine, lidocaine and ketamine while the other half will receive opioid based anesthesia with fentanyl, remi-fentanyl and ketamine
Since optimal analgesia for the obese patients undergoing bariatric surgeries has always been
challenging, and knowing the comorbidities and physiological changes in this population, use
of opioid-sparing agents during anesthesia has attracted substantial research.the use of
opioids in the perioperative period in obese patients is associated with an increased risk of
complications . They are especially more sensitive to the respiratory depressant effect of
opioids , thus any analgesic alternative without further compromising airway tone would be a
desirable choice.
Dexmedetomidine is a selective alpha-two adrenergic receptor agonist that has
antinociceptive, analgesic and sedative properties, without compromising airway tone and
reflexes .
Lidocaine, a local anesthetic that has been shown to be an effective multimodal strategy to
minimize postoperative pain was evaluated in one study involving obese patients undergoing
bariatric surgery. Its usage was associated with an improved quality of recovery compared to
placebo .
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