Postoperative Pain Clinical Trial
Official title:
Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy: A Randomized Controlled Trial
The aim of the current study is to compare a newly introduced material which is a combination of triple mix antibiotics paste and anti-hyperlipidemia drug simvastatin, the new material is named 3MIX-TATIN & will be compared to triple antibiotic paste for management of necrotic primary molars by using lesion sterilization and tissue repair LSTR technique.
3Mix-tatin will prepared by mixing three commercially available antibiotics with simvastatin.
After removing the coating materials, 3 types of antibiotics are pulverized by porcelain
mortars and pestles to achieve fine powders. A total of 100 mg ciprofloxacin, 100 mg
metronidazole, and 100 mg cefixime will be mixed in a ratio of 1: 1: 1. Two milligrams of
simvastatin will be added to the drugs blend to form 3-Mix-tatin. Preparation of 3Mixtatin
will be trained and supervised by an expert pharmacist. 3Mixtatin will be stored in a tightly
capped porcelain container, adding a small amount of silica gel in a bag inside the container
to maintain low humidity. This powder will be mixed with normal saline to form a creamy paste
of 3Mixtatin at the time of application.
Local anesthesia using mepivicaine hydrochloride 3% (septodont, saint-maurdesFosses, France)
will be administered.
Rubber dam isolation.
Access cavity will be prepared with a fissure bur in a high-speed handpiece, necrotic pulp
tissue will be removed using a sterile sharp spoon excavator.
The canal orifices will be enlarged with a round bur (one mm diameter and two mm depth) to
create medication receptacles.
Cotton pellet moistened with 2.5% sodium hypochlorite (NaOCl) will be placed in the pulp
chamber for 1 minute.
Bleeding, if present, will be controlled by applying sterile cotton pellet moistened with 10%
sodium hypochlorite against the pulp stumps and will be maintained for 1 min.
The 3-Mix-Tatin will be mixed with saline to obtain a creamy mix and placed over the canal
orifices and the pulpal floor.
The access opening will be sealed with a glass ionomer cement , and the tooth will be
restored with a stainless steel crown.
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