Study to Investigate TIVA With Propofol on Postoperative Pain and Side Effects

Postoperative Pain Clinical Trial

Official title:

Retrospective Study to Investigate Total Intravenous Anaesthesia (TIVA) With Propofol on Postoperative Pain and Side Effects After Surgery

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT03058354
• Other study ID #: UW17-001
• Status: Withdrawn
• Start date: January 1, 2017
• Est. completion date: December 31, 2020

Study information

• Verified date: October 2022
• Source: The University of Hong Kong
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Propofol is a commonly used anaesthetic with rapid recovery and less side effects and total intravenous anaesthesia (TIVA) with propofol is a common technique now. The reduction on certain serum pro- inflammatory cytokines may lead to more smooth post- surgical recovery.

Recent case report proved the analgesic effect of propofol infusion. However other animal and clinical studies showed controversial result.

The aim of this retrospective study is to investigate the postoperative analgesic effects and side effects of intraoperative TIVA with propofol in patient undergoing surgery at Queen Mary Hospital, Hong Kong between 2014 to 2016.

Description:

Objectives:

1. To investigate the analgesic effects of propofol.

2. To evaluate the effect of propofol on postoperative adverse events.

Methods:

Retrospective audit.

Data Collection:

1. Demographic data;

2. Types of analgesic techniques;

3. Type of pain relief modalities;

4. Pain score up to 72 hours postoperatively;

5. Postoperative opioid consumption;

6. Incidence of adverse events during APS care;

7. Patients' satisfaction on pain relief.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: December 31, 2020
• Est. primary completion date: December 31, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Anaesthetic records and acute pain service records of patient undergone surgery between 2014 to 2016 in Queen Mary Hospital would be retrieved from the computer.

Exclusion Criteria:

• Essential data were missing.

• Patient participating in other research projects.

• Changes in postoperative pain management technique.

• Patients could not be assessed post-operatively for pain (i.e. post-operative IPPV)

Related Conditions & MeSH terms

• Pain, Postoperative
• Postoperative Pain

Intervention

Drug:
• Propofol
Patient undergoing surgery at Queen Mary Hospital, Hong Kong between 2014 to 2016 using intraoperative TIVA with propofol.

Procedure:
• general anaesthesia
Patient undergoing surgery at Queen Mary Hospital, Hong Kong between 2014 to 2016 using general anaesthesia methods other than intraoperative TIVA with propofol.

Locations

Country	Name	City	State
Hong Kong	The University of Hong Kong	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
The University of Hong Kong

Country where clinical trial is conducted

Hong Kong, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	pain score	pain score using numeral rating scale	up to postoperative day 3
Secondary	analgesic consumption	analgesic consumption base on patient drug record	up to postoperative day 3