Intraoperative TIVA With Propofol on Postoperative Pain & Side Effects

Status Completed

Clinical Trial Summary

Postoperative pain can be severe after liver resection surgery. However, postoperative pain management may be difficult for this group of patients. Opioidergic neurotransmission may be altered in cirrhotic patients and selectively increasing receptor affinity for opioids. Large dose of strong opioid may be required to achieve adequate pain control. However, this may not be possible due to the side effect of opioid and liver dysfunction after liver resection. Propofol is a commonly used anaesthetic with rapid recovery and less side effects and TIVA (total intravenous analgesia) with propofol is a common technique now. The reduction on certain serum pro- inflammatory cytokines may lead to more smooth post- surgical recovery. Recent case report proved the analgesic effect of propofol infusion. However other animal and clinical studies showed controversial result. The aim of this retrospective study is to investigate the postoperative analgesic effects and side effects of intraoperative TIVA with propofol in patient undergoing liver resection surgery at Queen Mary Hospital, Hong Kong between 2010 to 2012.

Clinical Trial Description

Retrospective audit. Anaesthetic records and acute pain service records of patient undergone liver resection surgery between 2010 to 2012 in Queen Mary Hospital would be retrieved from the computer. Data Collection 1. Demographic data; 2. Types of analgesic techniques; 3. Type of pain relief modalities; 4. Pain score up to 72 hours postoperatively; 5. Postoperative opioid consumption; 6. Incidence of adverse events during APS care; 7. Patients' satisfaction on pain relief. Data Analysis For summarising analysis, mean or median with standard deviation or interquartile range will be reported. Parametric and non-parametric comparative tests will be used for analysis between/among patients with various characteristics. Kaplan Meier survival analysis and log-rank test will be used for duration of APS use. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02179437
Study type	Observational
Source	The University of Hong Kong
Contact
Status	Completed
Phase
Start date	August 1, 2014
Completion date	February 22, 2016

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Intraoperative TIVA With Propofol on Postoperative Pain and Side Effects After Liver Resection Surgery

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms