Postoperative Pain Clinical Trial
Official title:
Peripheral Nerve Block Anaesthesia for Ankle Fracture Surgery - an Exploratory Study: Is Rebound Pain a Problem?
The purpose of this exploratory study is to characterize the postoperative pain profile of
patients undergoing operation with internal fixation of an ankle fracture under nerve block
anaesthesia. Special attention is payed towards the possible existence and clinical
relevance of a rebound pain phenomenon upon cessation of the nerve block.
Results are used to guide the set up of a randomized controlled trial on the subject.
Peripheral nerve blocks (PNB) are widely used as anaesthesia and postoperative pain control
for surgery. Several studies have suggested multiple benefits of PNB's but primarily shown
in elective surgery. Acute conditions like ankle fractures have a different pain profile and
risks and benefits of PNB's have not been sufficiently researched in these cases.
A recent study (Goldstein et al. 2012) suggested that a rebound pain effect occur upon
cessation of PNB effect defined as a pain increase to a significantly higher level than
observed in patients with no PNB at the same point after surgery.
With this prospective, exploratory study we aim to examine the postoperative pain profile
after PNB anaesthesia for ankle fracture surgery with focus on plausibility of a rebound
pain effect (as defined above) upon PNB cessation.
Secondarily to explore a variety of factors related to postoperative pain profile and
feasibility of PNB anaesthesia for ankle surgery including efficacy, risk factors, time
factors as well as postoperative recovery and overall patient satisfaction. Results will
provide focus for a following randomized controlled trial.
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Observational Model: Cohort, Time Perspective: Prospective
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