Duration of Sciatic Nerve Block After Injection of Local Anesthetic In or Around the Nerve

Postoperative Pain Clinical Trial

Official title: Duration of Subgluteal Sciatic Nerve Block After Intra- or Perineural Injection of Mepivacaine: a Randomized, Controlled Trial

Status Completed

Clinical Trial Summary

This study was designed to assess whether the injection of local anesthetic into the nerve (intraneural), as opposed to around it (perineural), leads to longer anesthesia and analgesia of the leg.

Some reports of accidental intraneural injection mention an extremely long duration. When different drugs and doses were evaluated in a clinical trial of intraneural injection, a longer-than-expected duration was reported.

The investigators will compare the two types of injection using the same drug, so as to determine if there is an actual difference in duration.

Clinical Trial Description

This randomized, controlled trial will investigate prospectively for differences in sensory and motor block duration after intra- or perineural injection of 1.5% (wt/vol) mepivacaine, a short-acting local anesthetic. ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Orthopedic Surgical Procedures
• Pain, Postoperative
• Postoperative Pain

• NCT number: NCT01981291
• Study type: Interventional
• Source: University of Parma
• Status: Completed
• Phase: Phase 4
• Start date: October 2012
• Completion date: October 2013