Postoperative Pain Management Clinical Trial
Official title:
Efficacy of Intravenous Paracetamol and Ibuprofen on Postoperative Pain and Morphine Consumption in Hysterectomy: Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
To compare the effects of intravenous paracetamol and ibuprofen on postoperative pain and morphine consumption in patients undergoing hysterectomy surgery and the side effects associated with opioids.
All surgical procedures are associated with acute pain and inflammation, varying degrees of severity for the patients, causing significant stres and discomfort. Effective postoperative pain management in hysterectomy can reduce complications and improve postoperative care. In postoperative pain, multimodal analgesic techniques are used to provide synergistic effects through different nociceptive mechanisms. Hysterectomy is the second most common gynecological surgery performed after cesarean section. It is known that effective postoperative analgesia management decreases complications and increases patients' comfort. Various analgesics are used for pain. Opioids, frequently used for postoperative pain, are the most frequently used drug group. The combination of opioids with adjuvant agents may reduce the opioid consumption used systemically. Side effects such as sedation, respiratory depression, nausea, vomiting, rash and urinary retention that develop secondary to opioids may also be reduced by the combination of supplemental analgesics. Adjuvant agents, including nonsteroidal antiinflammatory drugs (NSAID), may be used in combination with opioids. NSAIDs do not only reduce pain, but also control the underlying inflammatory process. In addition, combining NSAIDs and opioids can help reduce the side effects by reducing administration of total opioid consumption. Intravenous ibuprofen is the first and only intravenous NSAID approved in the United States for both pain and fever control in adults. It has been reported in multicenter, randomized, double-blind, placebo-controlled studies that IV ibuprofen is safe and effective in postoperative pain management for abdominal hysterectomy and orthopedic surgeries. Intravenous paracetamol is an analgesic and antipyretic agent used as a first step drug for pain and fever control in adults and children. It has been clearly shown that IV paracetamol, with analgesic efficacy and safety profile, reduces analgesic requirements for pain management. It has also been shown that it provides better analgesic efficacy and reduces the opioid consumption when used in combination with opioids. The investigators aimed to compare the effects of intravenous paracetamol and ibuprofen on postoperative pain and morphine consumption in patients undergoing hysterectomy surgery and the side effects associated with opioids. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02516059 -
Early Postoperative Administration of Oxycodone +/- Naloxone and Duration of Epidural Analgesia
|
Phase 4 | |
Terminated |
NCT01736358 -
The Use of Intranasal Ketoralac for Pain Management (Sprix)
|
Phase 4 | |
Completed |
NCT00806806 -
Evaluate the Onset of Action of SKY0402 Following Local Infiltration in Healthy Volunteers
|
Phase 1 | |
Terminated |
NCT02143141 -
Low Pain Prediction in Cesarean Section Patients
|
Phase 4 | |
Recruiting |
NCT05011084 -
Combined Cryotherapy With Compression Versus Cryotherapy Alone After Orthopaedic Surgery
|
N/A | |
Terminated |
NCT03428984 -
Study in Adult Subjects Undergoing Posterolateral Thoracotomy
|
Phase 1 | |
Completed |
NCT04371341 -
A Comparative Study Between Different Volumes During Erector Spinae Block for Pain Control
|
N/A | |
Recruiting |
NCT06298370 -
The Efficacy of Combined Intrathecal Morphine and PENG Block on Postoperative Pain in Hip Arthroplasty
|
N/A | |
Completed |
NCT06028061 -
Evaluation of Effectivity of Quadratus Lumborum Blocks With Adjuvant
|
N/A | |
Completed |
NCT05401916 -
Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Tramadol Consumption in Shoulder Surgery
|
N/A | |
Terminated |
NCT03927911 -
Phase 4 Study in Adult Subjects Undergoing Posterior Lumbar Spine Surgeries
|
Phase 4 | |
Completed |
NCT01344213 -
Pregabalin, Celecoxib, Total Knee Arthroplasty and Intrathecal Morphine
|
Phase 4 | |
Completed |
NCT04434339 -
Ultrasound-guided Erector Spinae Plane Block Versus Transversus Abdominis Plane Block for Postoperative Analgesia of Adult Patients Undergoing Ovarian Cancer Surgery
|
N/A | |
Recruiting |
NCT02997215 -
Intravenous Lidocaine and Postoperative Pain Management
|
Phase 4 | |
Completed |
NCT01070108 -
Escalating Ketamine Doses and Pre-emption
|
N/A | |
Not yet recruiting |
NCT06148168 -
Magnesium Sulphate in Oblique Subcostal TAP Block
|
Phase 2/Phase 3 | |
Terminated |
NCT03015961 -
Phase 4, Controlled Study in Adult Subjects Undergoing Primary, 1-2 Level, Open Lumbar Spinal Fusion Surgery
|
Phase 4 | |
Completed |
NCT01726686 -
Pain Treatment After TKA With LIA and Intra-articular Continuous Infusion Pump
|
Phase 4 | |
Not yet recruiting |
NCT04525963 -
The Effect of Operating Room Nurse Visit Prior to Cardiac Surgery on Patients's Anxiety, Pain and Analgesic Use
|
N/A | |
Completed |
NCT03437707 -
Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Morphine Consumption in Lumbar Disc Surgery
|
N/A |