Intraoperative S-ketamine to Prevent Postoperative Hyperalgesia in Patients Undergoing Video-assisted Thoracic Surgery

Postoperative Hyperalgesia Clinical Trial

Official title: Second Affiliated Hospital Zhejiang University School of Medicine

Status Recruiting

Clinical Trial Summary

Postoperative hyperalgesia (POH) is a paradoxical clinical state of increased sensation of pain or increased sensitivity to non-painful stimuli at the site of surgery or at a surrounding area that was not directly injured. Opioid-induced hyperalgesia (OIH) and nociceptive-induced hyperalgesia (NIH) are the two main causes of POH.N-methyl-D-aspartate receptor (NMDAR) activation plays a central role in the development of POH.S-ketamine，which is a NMDA-receptor antagonist,has been on the market in china since 2019.The aim of this study is to evaluate the effects of S-ketamine on POH and chronic postoperative pain after video-assisted thoracic surgery.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Hyperalgesia
• Postoperative Hyperalgesia

• NCT number: NCT05016128
• Study type: Interventional
• Source: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Contact: LiNa Yu, doctor
• Phone: 13958033387
• Email: zryulina@zju.edu.cn
• Status: Recruiting
• Phase: N/A
• Start date: August 17, 2021
• Completion date: April 30, 2022