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Correlation Analysis of POD and PND in Elderly Spinal Surgery Patients Based on Rs-fMRI

Postoperative Delirium Clinical Trial

Official title:
Correlation Analysis of Postoperative Delirium and Postoperative Neurocognitive Disorder in Elderly Spinal Surgery Patients Based on Resting State Functional Magnetic Resonance Imaging

Clinical Trial Summary

This study is a prospective cohort study to investigate the differences in resting-state functional magnetic resonance imaging (fMRI) between elderly spinal surgery patients with postoperative delirium (POD) who either develop or do not develop long-term postoperative neurocognitive disorders (pNCD).

Clinical Trial Description

To investigate the differences in resting-state functional magnetic resonance imaging (fMRI) between elderly spinal surgery patients with postoperative delirium (POD) who either develop or do not develop long-term postoperative neurocognitive disorders (pNCD). Neurocognitive function of the study participants was assessed within one week before surgery using the Montreal Cognitive Assessment (MoCA). Perform baseline MRI scan before surgery. Under routine anesthetic management of the Department of Anesthesiology and Surgical Operations at Xuanwu Hospital, endotracheal intubation general anesthesia was performed. Within 7 days post-surgery, delirium assessment was conducted using the Confusion Assessment Method (CAM), classifying patients into POD and non-POD groups. Neurocognitive function assessments were conducted long-term after surgery for the POD group to determine the presence of pNCD, further dividing the POD group into pNCD and non-pNCD subgroups, followed by fMRI scanning.By comparing the patterns and intensities of brain functional connectivity between the pNCD and non-pNCD subgroups, a differential analysis was conducted on the effective connectivity and information flow of functional networks, exploring the state of the brain functional network during the process of POD and pNCD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06466083
Study type Observational [Patient Registry]
Source Xuanwu Hospital, Beijing
Contact lei zhao
Phone +8613811035886
Email zhaoalei@sina.com
Status Not yet recruiting
Phase
Start date June 14, 2024
Completion date July 1, 2026
View Details
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