Does Peri-Operative Gabapentin Reduce Chronic Post-Thoracotomy Pain?

Post-thoracotomy Pain Clinical Trial

Official title: Does Peri-Operative Gabapentin Reduce Chronic Post-Thoracotomy Pain?

Status Withdrawn

Clinical Trial Summary

The primary objective of this study is to determine if gabapentin can decrease or prevent chronic post-thoracotomy pain.

Clinical Trial Description

This study is a prospective double blind randomized controlled trial evaluating the peri-operative use of gabapentin in the prevention or modulation of post-thoracotomy hyperalgesia. Treatment will consist of a 600 mg dose of gabapentin or placebo given preoperatively the night before surgery, based on a computer generated randomized assignment. The treatment group will continue to be medicated with gabapentin 300 mg twice daily for one month following surgery. Those not included in the treatment arm of the study will continue to take a placebo for the same duration. Follow-up will consist of a postoperative visit at approximately 48 hours and a one month clinical visit. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Post-thoracotomy Pain

• NCT number: NCT00934193
• Study type: Interventional
• Source: University of Kansas Medical Center
• Status: Withdrawn
• Phase: Phase 3
• Start date: July 2009
• Completion date: June 2011