Effectiveness if Premedication With Single Dose Piroxicam and Prednisolone After a Single Visit Root Canal Treatment .

Post-operative Endodontic Pain Clinical Trial

Official title:

Effectiveness of Single Dose Pre Medication of Piroxicam and Prednisolone on Post Endodontic Pain After a One Visit Root Canal Treatment. Randomized Trial .

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04124822
• Other study ID #: Dikiohs2013
• Status: Completed
• Phase: Phase 2/Phase 3
• Start date: May 30, 2018
• Est. completion date: July 15, 2019

Study information

• Verified date: October 2019
• Source: Dow University of Health Sciences
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Two drugs (Piroxicam and Prednisolone)are being compared for post operative endodontic pain after a single visit root canal treatment for 74 hours.

Description:

To evaluate effectiveness of single dose premedication with piroxicam(20mg) and prednisolone(20mg) on post endodontic pain after a single visit root canal treatment .

patient will be recalled every day for 4 days to know the pain scale using visual analogue scale .

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: July 15, 2019
• Est. primary completion date: July 15, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 40 Years

Eligibility

Inclusion Criteria:

1. Patient ages from 20-40 years(28).

2. Single rooted tooth with symptomatic irreversible pulpitis.

3. With no analgesic or anti-inflammatory drug taken within a week period before procedure.

Exclusion Criteria:

1. Patients presenting with any systemic disease

2. Patients already taking premedication for endodontic pain.

3. Pregnant or lactating patients.

4. Multirooted teeth.

5. Teeth with Pulpal necrosis.

6. Previously treated or initiated root canal treatment.

7. Patient presenting with allergy due to drug

Related Conditions & MeSH terms

• Post-operative Endodontic Pain

Intervention

Drug:
• Piroxicam 20 mg
Piroxicm is from oxicam family of anti inflammatory drug that inhibits prostaglandin synthesis and effectively lower pain threshold levels
• prednisolone 20 mg
prednisolone is from steroid family of anti inflammatory drug that inhibit arachidonic acid and effectively lowers the pain

Locations

Country	Name	City	State
Pakistan	DUHS	Karachi	Sindh

Sponsors (1)

Lead Sponsor	Collaborator
Dow University of Health Sciences

Country where clinical trial is conducted

Pakistan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	post operative pain	post operative pain will be measured after single visit endodontic treatment using visual analog scale with readings 1 to 10 from 24 hours till 76 hours	76 hours