Post-operative Analgesia Clinical Trial
Official title:
Bilateral Ultrasound Guided Erector Spinae Plane Block Versus Transversus Abdominis Plane Block on Post-operative Analgesia After Total Abdominal Hysterectomy
- Abdominal hysterectomy is an open surgical procedure associated with considerable
post-operative pain. Narcotics are often required during patient recovery but can result
in adverse side effects. Transversus abdominis plane block(TAP block) is a regional
anesthetic technique that is found to be effective as post-operative analgesia after
total abdominal hysterectomy. Recently, erector spinae plane block(ESP)block is found to
be safe, and simple regional anesthetic technique that decrease total opioid consumption
in patient undergoing breast, or abdominal surgery.
- The aim is to compare the efficacy of bilateral erector spinae plane block, and
bilateral transversus abdominis plane block on postoperative analgesia in patients after
abdominal hysterectomy under general anesthesia, and their need for opioid.
Hypothesis
- Null hypothesis (H0): No difference between the analgesic effects of bilateral erector
spinae plane block, and bilateral transversus abdominis plane block in patients after
abdominal hysterectomy under general anesthesia.
- Alternative hypothesis (H1): There are difference between the analgesic effects of
bilateral erector spinae plane block, and bilateral transversus abdominis plane block in
patients after abdominal hysterectomy under general anesthesia.
Sample size: Assuming that Mean±SD of reduced pain scores in erector spinae plane block is
4.7±3.7 versus 2.5±1 in transversus abdominis plane block.So, the total sample size is 48
cases (24 in each group) using Open Source Statistics for Public Health (open Epi) with
confidence interval 95% and power of test is 80%.
d) Method of sample collection:
Forty eight female patients will be divided into two groups by a computer-generated
randomization table:
Group (ES) (n=24): will receive bilateral ultrasound guided erector spinae plane block with
each block 20 ml of bupivacaine 0.375% plus 5ug/ml adrenaline (1:200000) at the level of T9.
Group (TA) (n=24): will receive bilateral ultrasound guided transversus abdominis plane block
with each block 20 ml of bupivacaine 0.375% plus 5ug/ml adrenaline (1:200000).
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