Post-menopausal Status Clinical Trial
Official title:
Effects of a Long-term and Regular Grapefruit Juice Consumption on Vascular Protection and Bone Metabolism : a Cross-over Designed Study to Determine the Specific Role of Naringin
Verified date | July 2014 |
Source | University Hospital, Clermont-Ferrand |
Contact | n/a |
Is FDA regulated | No |
Health authority | France: Ministry of Health |
Study type | Interventional |
Epidemiological studies definitively show that fruit and vegetable consumption is an
important factor for the prevention of age-related diseases such as cardiovascular diseases
(CVD) and osteoporosis. Citrus fruits are among the fruits which are the most frequently
consumed worldwide, essentially as juices.
Citrus fruits are the exclusive sources of a particular class of dietary flavonoids, namely
flavanones. Grapefruit consumed as whole fruit or juice corresponds to a quantitatively
significant source of a specific flavanone called naringin.
Status | Completed |
Enrollment | 52 |
Est. completion date | December 2011 |
Est. primary completion date | December 2011 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 50 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Caucasian healthy post-menopausal women - 19= BMI =29 and waist measurement > 88 cm Exclusion Criteria: - Metabolic diseases - Hypertension - Taking CYP3A4-metabolized drugs - Taking blood lipids lowering drugs or antihypertensive drugs - Hypercholesterolemia with HDL < 1.30 mmol/L (i.e. < 0.5 g/L) - Osteoporosis (defined by T-score of -2.5 SD at hip and/or lumbar spine) - Taking hormone replacement therapy (HRT) - Smokers - Taking dietary supplements |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
France | CHU Clermont-Ferrand | Clermont-Ferrand |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Clermont-Ferrand | 63122 Saint-Genès Champanelle, Equipe MiMes, FRANCE, INRA de Clermont-Fd / Theix, UMR 1019 Unité de Nutrition Humaine |
France,