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Pain Relieving Potentials of Combination of Oral Duloxetine and Intravenous Magnesium Sulphate in Post Mastectomy Pain

Post-mastectomy Pain Syndrome Clinical Trial

Official title:
Pain Relieving Potentials of Preoperative Combination of Single Dose Oral Duloxetine and Intravenous Magnesium Sulphate in Acute and Chronic Post Mastectomy Pain: A Randomized Controlled Trial

Clinical Trial Summary

This study aims to evaluate the effect of combined duloxetine and IV Magnesium sulphate to decrease acute and chronic post mastectomy pain. The study will be conducted in National Cancer Institute and all the participants will be enrolled from female patients scheduled for modified radical mastectomy under general anesthesia in National Cancer Institute, Cairo University.

Clinical Trial Description

It has been reported recently that Duloxetine improved the quality of recovery in patients subjected to hysterectomy. In this context, mastectomy has a negative consequence starting from cancer diagnosis to the squeal of cancer-related treatments and it has been estimated that 20%-30% of patients with breast cancer suffer from depression and anxiety. Magnesium also antagonizes the release of inflammatory mediators such as histamine, serotonin, and cytokines in peripheral tissues. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06087211
Study type Interventional
Source National Cancer Institute, Egypt
Contact Norma Osama AbdAlla Zayed, MD
Phone 01067843111
Email normazayed@yahoo.com
Status Recruiting
Phase Phase 4
Start date October 10, 2023
Completion date April 2024
View Details
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