Clinical Trials Logo
  1. Home
  2. Post-mastectomy Pain Syndrome
  3. NCT06087211

Pain Relieving Potentials of Combination of Oral Duloxetine and Intravenous Magnesium Sulphate in Post Mastectomy Pain

Post-mastectomy Pain Syndrome Clinical Trial

Official title:
Pain Relieving Potentials of Preoperative Combination of Single Dose Oral Duloxetine and Intravenous Magnesium Sulphate in Acute and Chronic Post Mastectomy Pain: A Randomized Controlled Trial

Clinical Trial Summary

This study aims to evaluate the effect of combined duloxetine and IV Magnesium sulphate to decrease acute and chronic post mastectomy pain. The study will be conducted in National Cancer Institute and all the participants will be enrolled from female patients scheduled for modified radical mastectomy under general anesthesia in National Cancer Institute, Cairo University.

Clinical Trial Description

It has been reported recently that Duloxetine improved the quality of recovery in patients subjected to hysterectomy. In this context, mastectomy has a negative consequence starting from cancer diagnosis to the squeal of cancer-related treatments and it has been estimated that 20%-30% of patients with breast cancer suffer from depression and anxiety. Magnesium also antagonizes the release of inflammatory mediators such as histamine, serotonin, and cytokines in peripheral tissues. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06087211
Study type Interventional
Source National Cancer Institute, Egypt
Contact Norma Osama AbdAlla Zayed, MD
Phone 01067843111
Email normazayed@yahoo.com
Status Recruiting
Phase Phase 4
Start date October 10, 2023
Completion date April 2024
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT04874038 - Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN) Phase 3
Completed NCT02240199 - Perioperative Pregabalin and Lidocaine to Reduce Chronic Breast Cancer Pain Phase 3
Recruiting NCT05201963 - Erector Spinae Plane Block Versus Serratus Anterior Block on Post Mastectomy Pain Syndrome N/A
Completed NCT05458154 - Evaluation and Re-evaluation of Post-mastectomy Pain Syndrome by Breast Cancer EDGE Task Force Outcomes N/A
Recruiting NCT05935059 - The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery. N/A
Not yet recruiting NCT04317898 - Ultrasound-Guided Serratus Plane Block Vs Paravertebral Block For Chronic Post-mastectomy Pain. N/A
Active, not recruiting NCT04267315 - Trigger Point Injections for Post-Mastectomy Pain Syndrome Phase 2
Recruiting NCT05771103 - Stellate Ganglion Destruction With Alcohol Versus Thermal Ablation for Chronic Post Mastectomy Pain N/A
Recruiting NCT03965442 - Effects of Intraoperative Esmolol on Post-mastectomy Pain Syndrome
Not yet recruiting NCT04989179 - Incidence and Factors Affecting the Development and Outcome of Post Mastectomy Pain Syndrome
Recruiting NCT05770596 - Vitamin C on Acute and Chronic Post Mastectomy Pain N/A