Comparison of the Effect of Aminophylline, Magnesium Sulphate and Placebo in Prevention of Post Dural Puncture Headache in Parturient Undergoing Caesarean Section.

Post-Dural Puncture Headache Clinical Trial

Official title:

Comparison of the Effect of Aminophylline, Magnesium Sulphate and Placebo in Prevention of Post Dural Puncture Headache in Parturient Undergoing Caesarean Section. A Double-blind Placebo Controlled Trial.

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06272916
• Other study ID #: Effect drugs on headache inCS
• Status: Not yet recruiting
• Start date: March 2024
• Est. completion date: June 2025

Study information

• Verified date: February 2024
• Source: Assiut University
• Contact: Reham M. Abdelbary
• Phone: 01063211106
• Email: rehammohamed1304[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study will be conducted to better comprehend the effect of aminophylline in comparison to magnesium sulphate on preventing and/or treating PDPH.

Description:

Delivery by cesarean section (CS) is becoming more frequent and is one of the most common operative procedures performed worldwide. In the USA a CS rate of 26% for all births is reported (1). According to the data by the Central Agency for Public Mobilisation and Statistics (CAPMAS) on the Health of the Egyptian Family (HEF) in late August, C-section births increased to 72 percent in 2021. (2) The postpartum period is marked by the presence of post- dural puncture headache (PDPH) which is an unpleasant emotional and sensory experience. Therefore, any form of intervention that leads to improvement in pain/headache relief can positively impact on patients satisfaction and prevent long hospital stay.

Spinal anesthesia remains the most common analgesic and anesthetic modality in women undergoing CS. It has a worldwide acceptance; it is very reliable and safe as a form of obstetrics anesthesia. Spinal anesthesia also has a fast onset of action and its use is efficacious (3). Although, spinal anesthesia has a generally acceptable complication rate, PDPH has remained its major drawback and unpleasant complication. This complication is especially noticeable few hours after the procedure (4). Although there is no clear pathophysiologic mechanism for PDPH, many treatment options used frequently in clinical practice to prevent or treat headache have been tried but currently there is still no approach that has been shown to offer complete prevention or treatment of the PDPH. Apart from the choice of insertion technique, optimal needle size and tip (5).

The incidence of PDPH has been estimated between 1% and 40% based on the gauge and orientation of needles, the operator proficiency, etc. The incidence rate of PDPH can also be associated with the type of lumbar puncture.(6) Despite that the therapeutic mechanism of aminophylline on PDPH is not fully described yet (7), some studies suggest that it might be responsible for blocking adenosine receptors, constricting blood vessels, and blocking pain transmission. It also seems that aminophylline can increase the intracellular levels of cyclic adenosine monophosphate. Furthermore, calcium uptake by the endoplasmic reticulum of endothelial cells might be suppressed with the administration of aminophylline; this process induces CSF secretion.

Although the precise mechanism is uncertain, magnesium sulfate's ability to function as a noncompetitive antagonist of (NMDA) receptors among peripheral tissues as well as the central nervous system explains the analgesic effects. It also affects how much intracellular calcium is present (8).

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 630
• Est. completion date: June 2025
• Est. primary completion date: April 2025
• Gender: Female
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• All parturient who underwent cesarean section under spinal anesthesia.

• Patients who are willing to participate in the trial gave an informed consent.

• ASA physical status II.

• The age ranged from 20 to 40.

• Body Mass Index (BMI) ranged from 25 to 30 kg/m2.

Exclusion Criteria:

• Patient refusal.

• Allergy to the studied drugs.

• Patients with contraindications to spinal anesthesia.

• Those with past history of chronic headache or recent onset of acute headache were excluded.

• Women who had multiple punctures (>2) during the spinal anesthesia procedure were excluded from the study.

• Patients with advanced decompensated cardiac, renal, hepatic disease.

Related Conditions & MeSH terms

• Headache
• Post-Dural Puncture Headache

Intervention

Drug:
• Aminophylline , magnesium sulphate and placebo
Comparison of the Effect of Aminophylline, Magnesium Sulphate and Placebo in Prevention of Post Dural Puncture Headache in Parturient Undergoing Caesarean Section

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Effect of the study drugs on the incidence and severity of PDPH		100ml of the prepared study drug intravenously immediately after the baby was delivered and umbilical cord was clamped.