Hyperbaric Oxygen Therapy for Post-Concussion Syndrome

Status Recruiting

Clinical Trial Summary

The purpose of this study is to decrease symptom burden, improve cognitive function, and improve quality of life outcomes in subjects with mild TBI and persisting post-concussion syndrome using Hyperbaric Oxygen Treatment compared to a sham intervention. Specific Aims: 1. Evaluate the efficacy of hyperbaric oxygen treatment to improve outcomes for adults with persisting post-concussion syndrome. Specifically, the investigators hypothesize that a prescribed course of hyperbaric oxygen treatments (HBOT) will improve outcomes and quality of life in adults with persisting symptoms >3 months after injury. 1. Decrease symptom burden as measured by the Rivermead Post-Concussion Symptoms Questionnaire (RPQ). 2. Improve cognitive function as measured by the National Institutes of Health (NIH) Toolbox Cognition Battery. 3. Improve quality of life as measured by the 36-Item Short Form Survey (SF-36). 2. Assess the safety and tolerability of hyperbaric oxygen treatments and compliance with treatment in adults with persisting post-concussion syndrome.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05643482
Study type	Interventional
Source	University of Texas Southwestern Medical Center
Contact	Brittany Wright, PhD
Phone	469-443-4267
Email	HBOTConcussion@utsouthwestern.edu
Status	Recruiting
Phase	N/A
Start date	March 1, 2023
Completion date	September 2026

View Details

See also
Status	Clinical Trial	Phase
Withdrawn	`NCT05062148` - Fundamental and Applied Concussion Recovery Modality Research and Development: Applications for the Enhanced Recovery	N/A
Active, not recruiting	`NCT01874847` - PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin	Phase 2/Phase 3
Completed	`NCT01611194` - mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms	Phase 2
Recruiting	`NCT05328635` - Post-traumatic Headache Multidisciplinary Study
Active, not recruiting	`NCT03205215` - Hyperbaric Oxygen for Post Concussive Syndrome	N/A
Completed	`NCT03688984` - Treatment of Insomnia for Adolescents With Mild Traumatic Brain Injury	N/A
Recruiting	`NCT05889117` - Brain Stimulation for Concussion	N/A
Recruiting	`NCT04614922` - Acceptance and Commitment Therapy-based Rehabilitation of Post-concussion Symptoms	N/A
Recruiting	`NCT05072743` - Improvement in Sleep Symptomatology and Neurocognitive Function Using Photobiomodulation in Post-Concussion Patients	N/A
Completed	`NCT04681742` - Feasibility Testing of Cognitive Strategy Training in Post-Concussive Syndrome	N/A
Completed	`NCT03674398` - Aerobic Exercise and Cognitive Training Effects on Postconcussive Symptomology	N/A
Active, not recruiting	`NCT05635656` - Digital Solutions for Concussion	N/A
Recruiting	`NCT05631301` - Move&Connect: A Program for Youth With Concussion and Their Caregivers.	N/A
Recruiting	`NCT06015451` - Exercise in Postconcussion Symptoms and Posttraumatic Headache	N/A
Terminated	`NCT03339037` - Hyperbaric Oxygen Therapy Effect on Post Concussion Syndrome in Children	N/A
Completed	`NCT03895450` - Treating Persistent Post-concussion Symptoms With Exercise	N/A
Recruiting	`NCT02089594` - Hyperbaric Oxygen Treatment to Treat Mild Traumatic Brain Injury (mTBI)/Persistent Post-Concussion Syndrome (PPCS)	Phase 3
Active, not recruiting	`NCT04568369` - Treatment of Post-concussion Syndrome With TMS: Using FNIRS as a Biomarker of Response	N/A
Recruiting	`NCT04688255` - Mobile Subthreshold Exercise Program for Concussion--R01	N/A
Not yet recruiting	`NCT05785000` - Rehabilitation in Post Concussion Syndrome	N/A