Patient Registry of Posner-Schlossman Syndrome

Posner Schlossman Syndrome Clinical Trial

Official title:

Patient Registry of Posner-Schlossman Syndrome

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03233477
• Other study ID #: IRB00006761-2014166
• Status: Recruiting
• Start date: July 31, 2014
• Est. completion date: July 31, 2024

Study information

• Verified date: October 2020
• Source: Peking University
• Contact: Shushan Li, MD
• Phone: 0086-135-5237-4266
• Email: shushan_li[@]yeah.net
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Posner-Schlossman syndrome, or glaucomatocyclitic crisis, is a condition characterized by recurrent, acute attacks of mild, nongranulomatous, anterior uveitis accompanied by markedly elevated intraocular pressure. Most of patients are the 20 to 50-year-old young adults, with unilateral eye involvement. PSS was originally deemed benign, but is now recognized as a relatively rare cause of chronic secondary glaucoma,especially in patients with recurrent episodes. This relatively rare disease is likely the result of the infections of a variety of organisms, and the bulk of literature supports the cytomegalovirus (CMV) as the leading cause.

This study is an observational study that does not interfere with the normal clinical diagnosis and treatment process. The investigators in this study focus on observing the clinical symptoms and outcome of PSS, analyzing the factors that affect the prognosis of PSS, studying the association of its pathogenesis with the psychological status and the behavioral types of PSS patients; exploring the relationship between infection (CMV, HSV, Hp) and PSS; and studying the changes of local and systemic cytokine expression and its significance in patients with PSS.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 180
• Est. completion date: July 31, 2024
• Est. primary completion date: July 31, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 12 Years to 80 Years

Eligibility

Inclusion Criteria:

• Volunteer to take part in this study and sign informed consent by oneself or the patient's legal representative

• Clinical diagnosis of Posner-Schlossman Syndrome, age-related cataract, or primary open-angle glaucoma

• Live in Beijing, China or being able to visit the Peking University Third Hospital every year after the beginning of the study or whenever the disease relapses

Exclusion Criteria:

• Fit any exclusion criteria of the patient's group

Related Conditions & MeSH terms

• Posner Schlossman Syndrome
• Syndrome

Locations

Country	Name	City	State
China	Peking University Third Hosipital	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Peking University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	demographic characteristics	age, sex, education level, systemic disease, mental state	up to 10 years
Primary	visual acuity	uncorrected visual acuity and best corrected visual acuity	up to 10 years
Primary	intraocular pressure	Goldmann	up to 10 years
Primary	slit-lamp examination	anterior segment	up to 10 years
Primary	fundus photograph	analysis the morphology of optic nerve head	up to 10 years
Primary	OCT	zess	up to 10 years
Primary	visual field	Humphrey visual field	up to 10 years
Primary	blood serum	8ml	up to 10 years
Primary	aqueous humor	0.2ml	up to 10 years
Primary	tissue	iris and& or trabecular meshwork tissue abandoned in the anti-glaucoma operation	in the operation