Positron-Emission Tomography Clinical Trial
Official title:
A Pilot Clinical Study of PET Scanning in Evaluation of Vaccine Reactogenicity
This study forms part of an integrated, multi-study effort to identify potential biomarkers
of reactogenicity to vaccines. We have selected PET-CT as it is in routine clinical use and
has been serendipitously shown to image lymph nodes and injection site inflammation after
immunisation.The study's objectives are exploratory:
1. To methodically characterise relative anatomical distribution and intensity of
post-immunisation innate immune activation visualised by PET-CT after immunisation with
adjuvanted and non-adjuvanted vaccines.
2. To correlate PET/CT changes with diary card recorded symptoms of reactogenicity.
n/a
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