Polycystic Ovary Syndrome Clinical Trial
Official title:
Obesity and Clinical Presentation of Hyperandrogenism
Polycystic Ovarian Syndrome (PCOS) is the most common endocrine disorder in reproductive
women. It is estimated that 5 to 10% of women of reproductive age have PCOS. One of the major
diagnostic criteria of PCOS was chronic anovulation which lead to irregular menstruation,
amenorrhea, and infertility; the other diagnostic criteria was hyperandrogenism which lead to
hirsutism, acne and alopecia. Furthermore, PCOS is thought as a metabolic disorder, the
long-term consequence of PCOS were diabetes mellitus and cardiovascular disease, which are
potentially dangerous in women health. Early diagnosis and prevention is very important to
the PCOS patients.
Obesity is the most potential risk of threat to health of populations. There is a major
impact of obesity on the PCOS related disorders. Insulin resistance and distribution of
adipose tissue were thought to be the important risk factors of cardiovascular and metabolic
syndrome. To treat PCOS patients properly,Wan-Fang hospital had established a specific
medical team. The investigators recently published in "Fertility and Sterility" about the
clinical presentation of androgen excess in Taiwanese women. Hirsutism is much less
prevalence (30%) in Taiwanese PCOS women than that previous reported (65-80%) in theWestern
women. It is important to know that some clinical presentation of PCOS might have ethic
variance. Insulin resistance was reported as another candidate that might have ethic
variance. The investigators had reported about 40% women in PCOS women were obese, it is
similar with previous literature reported. Obesity is a major factor that could be controlled
during the treatment of PCOS.Weight reduction is one of our methods in PCOS treatment. The
progressive results for obese PCOS women would be facing the risks of diabetes and metabolic
syndrome. The investigators thought like to evaluate the benefit of weight reduction program
to the prognosis of obese women with PCOS.
Furthermore, it is known that Endothelial progenitor cells (EPC) be an early marker of
cardiovascular disease, the investigators would like to know the role of EPC to predict
metabolic syndrome in women with PCOS. Wan-Fang hospital has a professional team in PCOS
treatment and research which including gynecological endocrinologist, cardiologist, medical
endocrinologist, specialist in weight reduction. This team had been working well for more
that 4 years.
The investigators hope that we can make a contribution to the study and treatment of PCOS in
Taiwan.
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