Pneumonia Clinical Trial
— PLUS2Official title:
The Effect of Household Air Pollution on Lung Function Growth in Infants With Pneumonia in Sub-Saharan Africa
Verified date | October 2023 |
Source | Massachusetts General Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study will evaluate the feasibility and acceptability of a household-based clean air intervention
Status | Enrolling by invitation |
Enrollment | 25 |
Est. completion date | April 30, 2025 |
Est. primary completion date | April 30, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 1 Month to 11 Months |
Eligibility | Inclusion Criteria: - Age < 12 months • First episode of WHO-defined severe pneumonia22: cough or difficulty breathing with - Oxygen saturation < 90% or central cyanosis, - Severe respiratory distress, or - Signs of pneumonia with a general danger sign - Be willing to commit to entire 2 years of follow up visits. - (Controls) Matched to each case on age (+/-1 month), sex, and community Exclusion Criteria: - Craniofacial, cardiac or other major malformation - Neuromuscular condition that affects respiration - Outside Smart Discharges Project catchment area - Prior hospitalizations or known episodes of respiratory illness or episodes of pneumonia before index admission, |
Country | Name | City | State |
---|---|---|---|
Uganda | Mbarara University of Science and Technology | Mbarara |
Lead Sponsor | Collaborator |
---|---|
Massachusetts General Hospital | Mbarara University of Science and Technology |
Uganda,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Feasibility and acceptability of the clean intervention | Adherence with the intervention (% total up-time of the air purifier) | 2 years | |
Secondary | Air quality | PM2.5 concentration | Up to 2 years | |
Secondary | Pulmonary function testing | Pulmonary function testing will be performed in household members | Up to 2 years | |
Secondary | Acceptability of using air filter device | Acceptability will be assessed using structured interviews with participating households. | Up to 2 years |
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