Pneumonia Clinical Trial
Official title:
Baricitinib Therapy in COVID-19: A Pilot Study on Safety and Clinical Impact
Retrospective study on the efficacy of baricitinib in 12 COVID-19 patients with moderate pneumonia.
Baricitinib, an anti-Janus kinase inhibitor (anti-JAK) acting against JAK1 and JAK2 that
inhibits JAK1- and JAK2-mediated cytokine release, was recently described using
BenevolentAI's proprietary artificial intelligence-derived knowledge graph, as an agent that
reduces the endocytosis into target cells, and to inhibit the entry. Based on its potential
action on inhibition of SARS-CoV-2 entry, and on its known effects on reduction of cytokine
release, baricitinib therapy was proposed in patients with moderate pneumonia to explore: the
safety of this drug combined with antiviral (lopinavir-ritonavir) in COVID-19; as second
outcome, to evaluate the impact of baricitinib in terms of clinical, laboratory, respiratory
parameters, and reduction of ICU admission.
Baricitinib was combined with antivirals because it does not interact with them due to its
prevalent renal elimination.
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