Phase Ⅰa Clinical Trial of a Pneumococcal Vaccine

Status Completed

Clinical Trial Summary

Infections with Streptococcus pneumoniae often cause serious health problems, especially for infants and the elderly.Failure to cover all polysaccharide types is an even greater problem with adults than with children. The aim of the study is to preliminary evaluate the safety and immunogenicity of PBPV vaccine compared to placebo,in order to provide a basis for subsequent clinical trial design.

Clinical Trial Description

The polysaccharide vaccine protected 60% of elderly adults who were at risk for pneumococcal infection.However, pneumococci are highly diverse with respect to their capsular types , and the polysaccharide-protein conjugate vaccines will not protect against strains of the many capsular types not included in the vaccine.This experimental vaccine was covered 70% of all pneumococcal types, Subjects will receive three doses of PBPV vaccine on day 0,60 and 120 with different contents of 20μg,50μg,100μg each antigen in 18 to 49 years of age. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04087460
Study type	Interventional
Source	CanSino Biologics Inc.
Contact
Status	Completed
Phase	Early Phase 1
Start date	April 10, 2020
Completion date	June 30, 2022

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Phase Ⅰa Clinical Trial of a Pneumococcal Vaccine — P?CTPV

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms