Pneumonia Clinical Trial
— RASPCAPOfficial title:
Effectiveness of a Regional Antimicrobial Stewardship Program to Reduce the Length of Stay of Patients Admitted to Hospital With Community-acquired Pneumonia: a Pragmatic Multi-centre Clinical Study
NCT number | NCT02276092 |
Other study ID # | RASP2013 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | April 2015 |
Est. completion date | April 2017 |
Verified date | January 2020 |
Source | Royal Victoria Hospital, Canada |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
This study evaluates the effectiveness of an antimicrobial stewardship program to reduce the length of stay of patients admitted to hospital with a diagnosis of pneumonia. The antimicrobial stewardship program will be implemented in several hospitals in Ontario, Canada. The program will identify patients with pneumonia, review their charts and make recommendations to their attending physicians about antibiotic management.
Status | Completed |
Enrollment | 1400 |
Est. completion date | April 2017 |
Est. primary completion date | March 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Community-acquired pneumonia - Immunocompetent - Age > 18 years Exclusion Criteria: - Admitted to an intensive care unit or high intensity unit - Requiring invasive or non-invasive ventilation - Life expectancy less than 3 months - Hospitalization within the previous 3 months for at least 48 consecutive hours - Immunocompromised defined as defined as having leukemia, lymphoma, HIV with CD4 count <=200, splenectomy or on cytotoxic chemotherapy - Neutropenic [defined as a PMN count<=0.5x109 cells/L] from any cause - Receiving immunosuppressants [defined as >=40 mg prednisone daily (or steroid equivalent) for >=2 weeks preceding hospitalization OR any other immunosuppressant used for systemic illness OR to prevent transplant rejection |
Country | Name | City | State |
---|---|---|---|
Canada | Royal Victoria Regional Health Centre | Barrie | Ontario |
Lead Sponsor | Collaborator |
---|---|
Royal Victoria Hospital, Canada |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Length of hospital stay | Time (measured in days) from date of admission to one of the following potential outcomes, discharge alive, censoring at 14 days post admission, death, admission to an intensive care unit, or transfer to another hospital | Days from time of admission to time of discharge from hospital to a maximum of 14 days from the date of admission (or time to censoring at 14 days from the date of admissionor competing event depending on which comes first) | |
Secondary | Days of antibiotic therapy | Total days of antibiotics administered for the treatment of community-acquired pneumonia | Days of antibiotic therapy for the treatment of pneumonia measured from the first day of antibiotic administered to the final day of antibiotic administered upto a maximum of 80 days | |
Secondary | Mortality rate | Deaths that occur post-discharge from hospital up to 30 days post-discharge | 30 day post-discharge from hospital | |
Secondary | Readmission to hospital | Readmissions to hospital that occur post-discharge from hospital up to 30 days post-discharge | 30 day post-discharge from hospital |
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