Pneumonia Clinical Trial
Official title:
A Randomized, Double-Blind, Comparative, Multi-Center Study of the Safety and Efficacy of TG-873870(Nemonoxacin) Versus Levofloxacin in Adult Patients With Community-Acquired Pneumonia (CAP)
1. This study will test the safety and efficacy of TG-873870 (Nemonoxacin) compared with
Levofloxacin in adult patients with Community-Aquired Pneumonia (CAP)
2. To investigate the population pharmacokinetics (PPK) of nemonoxacin in adult patients
with CAP after continuous oral administration and determine the pharmacokinetic
(PK)/pharmacodynamic (PD).
Community-acquired Pneumonia (CAP) remains a leading cause of death in both developing and
developed countries. In the choice of antibacterial agents used to treat CAP,
fluoroquinolones have received considerable attention because of their wide spectrum of
bactericidal activity. TG-873870 (Nemonoxacin), a non-fluorinated quinolone (NFQ), is a
selective bacterial topoisomerase inhibitor. This study will test the safety and efficacy of
TG-873870 (Nemonoxacin) compared with Levofloxacin in adult patients with Community-Aquired
Pneumonia (CAP).
Besides,the population pharmacokinetics (PPK) of nemonoxacin in adult patients with CAP
after continuous oral administration and determine the pharmacokinetic (PK)/pharmacodynamic
(PD).
;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment
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