Pneumonia Clinical Trial
— OvidiusOfficial title:
Dexamethasone Infusion in Community-acquired Pneumonia
The purpose of this study is to determine whether dexamethasone reduces the length of hospital stay in patient with a community-acquired pneumonia.
Status | Completed |
Enrollment | 300 |
Est. completion date | September 2010 |
Est. primary completion date | September 2010 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: Patients aged 18 to 100 years with a community-acquired pneumonia. Criteria to determine a community-acquired pneumonia: - Chest radiograph showing new opacities - In combination with two of the following findings: - Cough - Production of sputum - Temp >38,0 °C or <36,0 °C - Audible abnormalities by chest examination compatible with pneumonia - Leukocytosis (>10.000 cells/mm3), leftward shift (>10%) or leukopenia (<4000 cells/mm3) - CRP > 15 mg/dl (three times upper limit of normal) Exclusion Criteria: - o The following groups are excluded: - Immunocompromised patients: - Patients with a known congenital or achieved immunodeficiency. - Patients who received chemotherapy less than 6 weeks ago. - Patients who received corticosteroids in the last 6 weeks. - Patients who received immunosuppressive medication in the last 6 weeks. (like cyclosporine, cyclofosfamide, azathioprine) - Patients with COPD who are on systemic corticosteroids for COPD. - Patients who require ICU treatment. |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Netherlands | Gelderse Vallei Ede | Ede | Gelderland |
Netherlands | St Antonius Hosptial | Nieuwegein | Utrecht |
Lead Sponsor | Collaborator |
---|---|
St. Antonius Hospital |
Netherlands,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | length of hospital stay | 30 days | Yes | |
Secondary | side-effects inflammation markers lung function | 30 days | Yes |
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