Pneumonia Clinical Trial
Official title:
Dexamethasone Infusion in Community-acquired Pneumonia
The purpose of this study is to determine whether dexamethasone reduces the length of hospital stay in patient with a community-acquired pneumonia.
Community-acquired pneumonia (CAP) is common and approximately 20 percent of all episodes of
pneumonia result in hospitalization. It is the leading cause of community-acquired infection
requiring ICU admission.1 Especially elderly patients may have a severe illness with a high
morbidity and mortality rate. In pulmonary infections, the release of cytokines and other
inflammatory mediators from alveolar macrophages serves as a useful mechanism in the
elimination of invading pathogens. However, this natural reaction can be potentially harmful
when excessive release of circulating inflammatory cytokines causes damage to the patient,
particularly the lung.
Interest in the role of corticosteroids in the pathophysiology of critical illness has
existed since the early part of the 20th century. On ICU, early treatment with
corticosteroids to attenuate systemic inflammation is widespread. At the same time, outside
the ICU little evidence is available on the effect of treatment with corticosteroids in
patients diagnosed with CAP. Hypothetically, early initiated administration of
corticosteroids in the course of a CAP can lower systemic and pulmonary inflammation. This
may lead to earlier resolution of pneumonia and a reduction of complications (sepsis,
mortality).
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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