Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients

Pneumonia Clinical Trial

Official title:

Arginine Therapy for Acute Chest Syndrome in Sickle Cell Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00029731
• Other study ID #: FD-R-1978-01
• Secondary ID: FD-R-001978-01
• Status: Completed
• Phase: Phase 2
• First received: January 21, 2002
• Last updated: March 24, 2015
• Start date: August 2001
• Est. completion date: July 2005

Study information

• Verified date: January 2002
• Source: FDA Office of Orphan Products Development
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

This is a study to determine if oral arginine will increase nitric oxide in sickle cell disease (SCD) patients with acute chest syndrome (ACS). It will also assess the effects of arginine in the body and how the body uses nitric oxide in ACS.

Description:

Pneumonia in patients with SCD can be particularly severe and has come to be called acute chest syndrome. ACS is a common cause of morbidity in SCD patients and is the most common cause of death in SCD. Multiple factors are involved in the severity of acute pulmonary injury in SCD. Nitric oxide has a multitude of related functions, many of which could impact favorably on ACS in SCD. Nitric oxide is an important inflammatory mediator which is produced by the conversion of L-arginine to citrulline by nitric oxide synthase. Nitric oxide and its precursor, arginine, are known to be low in SCD patients with ACS, suggesting that therapies, such as arginine, aimed at increasing nitric oxide production will improve the clinical course of ACS. Patients will receive 1 of 3 doses of arginine hydrochloride orally 3 times a day for 3 days while hospitalized. The efficacy of arginine will be measured by the increase in nitric oxide production and the physiological effects will be assessed.

Completion date provided represents the completion date of the grant per OOPD records

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: July 2005
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 5 Years and older

Eligibility

Inclusion criteria:

• Diagnosis of sickle cell disease (Hb SS, SC, or Sbeta thalassemia)

Acute chest syndrome with the following:

• New pulmonary infiltrate on chest radiography involving a full segment of the lung and 1 of the following:

• Fever

• Cough, tachypnea, retractions, rales, or wheezing

• Chest pain

Exclusion criteria:

• Inability to take or tolerate oral medications

• Hepatic dysfunction (SGPT greater than 2 times normal)

• Renal dysfunction (creatinine greater than 2 times normal)

• Mental status or neurological changes

• Allergy to arginine

• History of priapism

• Pregnancy

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Acute Chest Syndrome
• Anemia, Sickle Cell
• Pneumonia

Intervention

Drug:
• Arginine hydrochloride

Locations

Country	Name	City	State
United States	Children's Hospital Oakland	Oakland	California

Sponsors (1)

Lead Sponsor	Collaborator
Children's Hospital & Research Center Oakland

Country where clinical trial is conducted

United States,