Pneumonia, Pneumococcal Clinical Trial
Official title:
Comparison Between Ceftriaxone and Levofloxacin on Cytokine Expression Over Time in Severe Pneumococcal Pneumonia
The purpose of this study is to compare levofloxacin vs ceftriaxone impact on the cytokine production in patients with pneumococcal pneumonia.
Bacterial alveolar invasion is followed by a compartmentalized inflammatory response. Data
suggest that some antimicrobials may induce a differential release of cytokines, with the
potential of either accelerating or down regulating cytokine production.
The aim of our study was to compare the effects of ceftriaxone compared with levofloxacin on
cytokine systemic concentrations in patients with pneumococcal pneumonia.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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