Pneumococcal Disease Clinical Trial
Official title:
A PHASE 1, RANDOMIZED, DOUBLE-BLIND STUDY OF THE SAFETY AND IMMUNOGENICITY OF A MULTIVALENT PNEUMOCOCCAL CONJUGATE VACCINE WITH AN ADJUVANT ADMINISTERED IN ADULTS 50 THROUGH 64 YEARS OF AGE
The purpose of this clinical trial is to learn about a pneumococcal vaccine with a new ingredient (PF-07872411) intended to enhance the effects of the vaccine. This pneumococcal vaccine with the new ingredient may prevent the diseases caused by pneumococcal bacteria like meningitis, sepsis, ear infections and sinusitis. Meningitis is an infection in which the tissue around the brain and spine is swollen. Sepsis is a very serious infection in your blood caused by a germ (a bacteria). Sinusitis is when your sinuses (the air-filled spaces inside your nose and head), are infected. This study is seeking for healthy participants who: - are above 50 years of age and less than 64 years of age. - have not taken any vaccine for pneumococcal diseases before. - have not taken any vaccines with additional ingredients within 1 year before administration of the study vaccine. All participants will receive a single study vaccine shot in the upper arm muscle at the study clinic. The study will compare the experiences of people receiving the vaccine with a new ingredient in the vaccine to those without the new ingredient. This will be done by comparing 2 different dose levels of the new ingredient. It will also be compared against people who receive the vaccine without the new ingredient and at different dose levels. This will help the study team establish if the vaccine with a new ingredient is safe and effective. Participants will take part in this study for about 12 months. During this time participants will have up to 6 clinic visits. At these clinic visits, participants will be asked if any side effects were experienced. The participants will also have to give blood samples during these visits. Some participants will need to have blood taken for laboratory tests before they can be judged to be eligible to be included in the study.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04546425 -
20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study of a 3-Dose Series in Healthy Infants
|
Phase 3 | |
| Recruiting |
NCT06044077 -
A Clinical Trial to Evaluate the Immunogenicity and Safety of the 23-valent Pneumococcal Polysaccharide Vaccine in Healthy People
|
Phase 3 | |
| Completed |
NCT02146365 -
Nasopharyngeal Carriage Study in Healthy Kenyan Toddlers
|
||
| Completed |
NCT04525599 -
A Study to Assess the Safety, Tolerability and Immunogenicity of ASP3772, a Pneumococcal Vaccine, in Toddlers 12 to 15 Months of Age in Comparison to an Active Comparator
|
Phase 1 | |
| Active, not recruiting |
NCT05512819 -
A Study to Describe the Safety and Immunogenicity of 20vPnC in Infants in India and Taiwan
|
Phase 3 | |
| Completed |
NCT04530838 -
20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study in Healthy Japanese Infants
|
Phase 3 | |
| Active, not recruiting |
NCT06026748 -
A Phase I Study of XJ103 in Chinese Healthy Subjects
|
Phase 1 | |
| Completed |
NCT04526574 -
Safety and Immunogenicity of 20vPnC Coadministered With SIIV in Adults ≥65 Years of Age
|
Phase 3 | |
| Completed |
NCT05329259 -
A Study to Describe the Safety of a Vaccine (Called 13vPnC) in Healthy People 18 to 49 Years of Age in India
|
Phase 4 | |
| Completed |
NCT00234338 -
Study Evaluating Prevenar in High-Risk Children
|
N/A | |
| Completed |
NCT01767402 -
Study to Evaluate Safety, Reactogenicity and Immunogenicity of the Pneumococcal Protein PhtD Vaccine in Healthy Adults
|
Phase 1 | |
| Active, not recruiting |
NCT05569954 -
Safety and Immunogenicity of V116 in Pneumococcal Vaccine-naïve Adults 50 Years of Age or Older (V116-010, STRIDE-10)
|
Phase 3 | |
| Completed |
NCT01111214 -
Child Pneumococcal Serotype Epidemiology In Greece
|
N/A | |
| Completed |
NCT01298544 -
A Study to Assess the Antibody Response of Healthy Chinese Children Who Have Been Vaccinated Previously With 4-doses of Prevenar (a Pneumococcal Vaccine) as Babies and Toddlers
|
Phase 4 | |
| Completed |
NCT04830358 -
Safety and Immunogenicity of the 'EuPCV15' in Healthy Korean Adults
|
Phase 1 | |
| Completed |
NCT04379713 -
20-valent Pneumococcal Conjugate Vaccine Safety Study in Healthy Infants
|
Phase 3 | |
| Completed |
NCT04887948 -
Safety and Immunogenicity Study of 20vPnC When Coadministered With a Booster Dose of BNT162b2
|
Phase 3 | |
| Completed |
NCT04382326 -
20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study of a 4-Dose Series in Healthy Infants
|
Phase 3 | |
| Not yet recruiting |
NCT00843895 -
Multicenter Prospective Evaluation of the Incidence and Serotyes of Invasive Pneumoccocal Disease (IPD) Among Children Below 5 Years
|
N/A | |
| Completed |
NCT01734239 -
A Phase III Clinical Trial to Study the Safety and Immunogenicity of Pneumovax™ 23 (V110) in Participants From the Russian Population (V110-018)
|
Phase 3 |