Clinical Trials Logo

Clinical Trial Summary

We aim to conduct a pilot trial assessing oral versus intravenous therapy for pleural space infections.


Clinical Trial Description

Pleural space infections are a frequent clinical problem resulting in significant morbidity and mortality as well as healthcare cost. Despite the increasing burden of disease, there are no clinical trials evaluating antibiotic therapy in pleural space infections. Hence, British and American guidelines are only able to provide weak and vague recommendations regarding duration, type or route (intravenous or oral) of antibiotic therapy. Our goal is to determine whether oral (PO) therapy is non-inferior to intravenous (IV) therapy thereby decreasing risks of IV catheter related infections, vein thrombosis and health care costs. Similar studies have been successfully conducted in the setting of bone/joint infections and endocarditis and showed non-inferiority of oral antibiotics. However, in order to help ensure that the randomized trial is of good quality, it is important to assess the feasibility of such a trial by first conducting a pilot study. The goal of this pilot trial is to assess the feasibility of the proposed study design. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04301869
Study type Interventional
Source St. Joseph's Healthcare Hamilton
Contact
Status Not yet recruiting
Phase N/A
Start date May 2020
Completion date December 2021

See also
  Status Clinical Trial Phase
Completed NCT04615286 - Short Versus Long Antibiotic Course for Pleural Infection Management (SLIM Trial) N/A
Recruiting NCT05910112 - Prospective Data Collection on Clinical, Radiological and Patient Reported Outcomes After Pleural Intervention
Recruiting NCT06141174 - Predictors of Outcome in Patients With Pleural Infection at Sohag University Hospital
Completed NCT03468933 - Fibrinolysis Compared to Thoracoscopy for Pleural Infection Phase 4
Completed NCT02608814 - Advanced Ultrasound in Pleural Infection N/A
Completed NCT04761133 - Antiseptic Irrigation for Pleural Infection Phase 1
Not yet recruiting NCT06427538 - Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas N/A
Not yet recruiting NCT05766124 - Trial of Reduced Alteplase Dose for Parapneumonic Effusion (TRAPPE) Phase 2/Phase 3
Completed NCT02973139 - Fibrinolysis Compared to Thoracoscopy for Pleural Infection N/A
Recruiting NCT05903417 - Pleural Irrigation With Normal Saline Versus Intrapleural Fibrinolytic N/A
Not yet recruiting NCT06434324 - Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic Effusion N/A
Completed NCT04569110 - The Microbiology of Pleural Infection
Recruiting NCT05702580 - Fluid Agitation Microbiologic Yield In Pleural Infection Feasibility Study N/A
Completed NCT04350502 - Pharmacokinetics and Pleural Fluid Penetration of Amoxicillin and Clavulanic Acid in Patients With Pleural Infections N/A