Pleural Effusion Clinical Trial
Official title:
The Effect of Perioperative Non-Steroidal Anti-Inflammatory Drug Naproxen on Pleural Effusion Formation After Lung Resection
Following a lung resection procedure, patients have their pleural space drained of fluid that accumulates due to the severing of proximal vessels like lymph nodes. The volume of fluid pumped depends on the severity of the inflammation. The investigators are conduction this study to attempt to use painkillers with intrinsic anti-inflammatory action to try and reduce the degree of inflammation in patients' pleural cavity, thus ensuring patients are discharged faster, with a greater comfort level, and a hopefully lower rate of admission.
In this study the investigators will attempt to reduce the degree of inflammation (and thus
polymorphonuclear leukocyte counts) in the pleural space following a lung resection procedure
by administering the Non Steroid Anti-Inflammatory Drug (NSAID) Naproxen in tandem with
Proton Pump Inhibitor (PPI) Pantoprazole, ideally leading towards a significantly reduced
volume of transudate and exudate generated.
This will be achieved by running a placebo-controlled double blinded randomized control trial
where investigators and participants will be blinded so as to eliminate experimenter bias.
After screening for suitable participants using stringent inclusion and exclusion criteria,
patients will be administered by allied health professionals 500mg Naproxen twice daily and
40mg Pantoprazole once daily, or an identical placebo for four weeks following resection
surgery. Patients will undergo a thorough examination during their scheduled follow-up
appointments to monitor general vitals as well as possible gastrointestinal complications.
The primary outcome is a significant reduction (Δ100ml) of chest fluid extracted in the
intervention arm of the study in comparison to that of the control arm. Secondary outcomes
will include a reduction in length of stay measured in days between control and intervention
arms as well as a reduction in the total number of days chest tubes are retained in-situ.
Conditions such as mortality and morbidity, the onset of complications, and general
re-admission rates will also be recorded.
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