Clinical Trials Logo
  1. Home
  2. Placental Insufficiency
  3. NCT03731611

Impact of Umbilical Cord Milking in Preterm Neonates With Placental Insufficiency

Preterm Infant Clinical Trial

Official title:
Impact of Umbilical Cord Milking in Preterm Neonates With Placental Insufficiency

Clinical Trial Summary

To investigate the effect of umbilical cord milking (UCM) on peripheral hematologic parameters including hematopoietic progenitor cells in premature infants ≤ 34 weeks gestational age with placental insufficiency. We hypothesize that UCM would enhance peripheral CD34 concentration, hemoglobin and reduce prematurity complications like NEC and IVH in preterm infant ≤ 34 week gestational age with placental insufficiency.

Clinical Trial Description

A pilot prospective randomized controlled study will be conducted among 3 groups, all of them are preterm less than 34 weeks gestational age, in the first group umbilical cord milking will be done for preterm infant with placental insufficiency. Two control groups are present, in the first one umbilical cord milking will be done for preterm infants without placental insufficiency (Insufficiency vs. no insufficiency), another group of immediate cord clamping for preterm infants with placental insufficiency will be added (milking vs. no milking), 30 cases will be recruited in each group. Umbilical cord milking (UCM) is typically performed by placing the infant below the level of the placenta. The cord is held at 20-25 cm distance from the baby and milked vigorously towards the umbilicus for 3 times at a speed of 10 cm/sec. After completion, the cord is clamped, and the neonate is handed to the resuscitation team. One milliliter of fetal blood will be taken from peripheral venous blood in the first 30 min of life and CD34 will be assessed by flow cytometry. Secondary outcomes will be documented during NICU stay that include admission CBC, peak bilirubin concentrations, CBC after 2 months, neonatal morbidity such as sepsis, bronchopulmonary dysplasia, necrotizing enterocolitis, retinopathy of prematurity and polycythemia, therapeutic interventions such as need for inotropes, nasal CPAP, mechanical ventilation and phototherapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03731611
Study type Interventional
Source Mansoura University Children Hospital
Contact
Status Completed
Phase N/A
Start date April 1, 2019
Completion date March 30, 2020
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT04062513 - Olfactive Stimulation Interventions With Mothers' Milk on Preterm Pain Response N/A
Completed NCT03412578 - Effect of Tactile/Kinaesthetic Massage Therapy on DXA Parameter of Preterm Infants N/A
Completed NCT03166722 - Cerebral Regional Tissue Oxygen Saturation to Guide Oxygen Delivery in Preterm Neonates During Immediate Transition N/A
Enrolling by invitation NCT03212547 - The Effect of a Neonatologist's Standardized Guidance Intervention on Preterm Infants With Relational Withdrawal. N/A
Completed NCT03931902 - The Comparison of Laryngeal Mask Airway and Endotracheal Tube in General Anesthesia for Premature Neonates N/A
Completed NCT03302000 - Visual Stimulation of Preterm Infants N/A
Completed NCT03731546 - Effect of Delayed Cord Clamping in Preterm Neonates With Placental Insufficiency N/A
Completed NCT03104946 - To Research the Relation Between Neonatal Morbidities and Poor Outcome in Preterm Infants N/A
Completed NCT03704012 - Efficacy of Massage Applied by the Parents in Hospitalized Premature Birth (PreMas) N/A
Suspended NCT03220282 - The Milk, Growth and Microbiota Study N/A
Active, not recruiting NCT03232931 - Trial to Improve Multisensory Neural Processing, Language & Motor Outcomes in Preterm Infants N/A
Completed NCT03242057 - Comparison of Primary Extubation Failure Between NIPPV and NI-NAVA N/A
Completed NCT04089540 - New Intubation Method to Achieve Circulatory Stability and to Reduce Number of Intubation Attempts in Neonates N/A
Not yet recruiting NCT02528851 - Cardiorespiratory Effects of "Higher" Versus "Equivalent" CPAP Upon Extubation From High EAP in Preterm Infants N/A
Completed NCT01959737 - Delivery Room Skin-to-skin Study N/A
Completed NCT03700463 - Executive Functions and Preterm Children in 3 to 4 Year Old
Completed NCT02811432 - Kangaroo Mother Care Before Stabilisation Amongst Low Birth Weight Neonates in Africa N/A
Completed NCT03728764 - Growth and Safety of a Two-stage Feeding System in Preterm Infants N/A
Completed NCT04382976 - The Incidence and the Risk Factors of Nephrocalcinosis in Very Preterm Infants
Completed NCT03748914 - C-UCM and Cerebral Oxygenation and Perfusion N/A