Metaplasticity in Human Pharyngeal Motor Cortex

Status Completed

Clinical Trial Summary

The purpose of the study is to determine the effects of giving 2 doses of brain stimulation through repetitive transcranial magnetic stimulation (rTMS) on swallowing neurophysiology (brain function) in healthy adults.

Clinical Trial Description

Recent studies have suggested that repetitive transcranial magnetic stimulation (rTMS), which is a well-established and tried and tested non-invasive (no surgical procedures involved) brain stimulation technique that can vary brain activities, may be used as a treatment for patients with swallowing difficulties. However, results have also showed that the response to the treatment is different among individuals. A possible explanation for this variation is related to the brain's level of activity preceding rTMS. The hypothesis of this study is that this variation may be minimized by regulating the brain state with an additional dose of rTMS prior to the intended rTMS session (preconditioned rTMS). This may subsequently improve the outcomes of rTMS. Therefore, this study aims to better regulate the response of the brain to rTMS. The findings of this study will provide the basis for future development of optimal rTMS treatment protocols for patients with swallowing difficulties. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03705936
Study type	Interventional
Source	University of Manchester
Contact
Status	Completed
Phase	N/A
Start date	October 24, 2018
Completion date	February 26, 2020

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