Pheochromocytoma Clinical Trial
— CASEOfficial title:
China Adrenal Disease Registry Study
Epidemiologic studies have revealed a tremendous increase in the prevalence of adrenal associated disease and related mortality worldwide. In order to meet all the therapeutic challenges in adrenal disease in China, CASE was founded in 2020. The objective of CASE is to launch an adrenal disease management model based on the Internet health information platform which allows the application and evaluation of adrenal disease treatment strategies at multiple centers. The proprietary electronic medical database will help the dynamic big-data analysis in epidemiology of adrenal disease, diagnosis, and treatment.
Status | Recruiting |
Enrollment | 2000 |
Est. completion date | April 30, 2026 |
Est. primary completion date | April 30, 2026 |
Accepts healthy volunteers | |
Gender | All |
Age group | 16 Years to 75 Years |
Eligibility | Inclusion Criteria: 1. Age = 16 years old and = 75 years 2. Patients diagnosed with adrenal associated diseases, including cushing syndrome, primary aldosteronism, primary hypoadrenalism, congenital adrenal hyperplasia and adrenal adenomas, incidentalomas, and carcinomas, pheochromocytoma, etc. 3. Provide written informed consent 4. Satisfactory compliance Exclusion Criteria: 1. Patients with significantly reduced life expectancy (less than 2 years) 2. With Drug abuse 3. With AIDS or syphilis or infectious diseases such as viral tuberculosis in active phase at enrollment |
Country | Name | City | State |
---|---|---|---|
China | Endocrinology | Shanghai |
Lead Sponsor | Collaborator |
---|---|
Shanghai Jiao Tong University School of Medicine |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Percentage of adrenal diseases in China | through study completion, an average of 1 year | ||
Primary | Number of participants with complication of adrenal diseases in China | through study completion, an average of 1 year | ||
Secondary | concentration of aldosterone | through study completion, an average of 1 year | ||
Secondary | concentration of cortisol | through study completion, an average of 1 year | ||
Secondary | concentration of urine cortisol | through study completion, an average of 1 year | ||
Secondary | concentration of androstenedione | through study completion, an average of 1 year | ||
Secondary | concentration of adrenocorticotropic hormone | through study completion, an average of 1 year | ||
Secondary | concentration of 17-hydroxyprogesterone | through study completion, an average of 1 year | ||
Secondary | concentration of metanephrines | through study completion, an average of 1 year | ||
Secondary | changes in adrenal CT | through study completion, an average of 1 year | ||
Secondary | percentage of hypoadrenalism | through study completion, an average of 1 year | ||
Secondary | Mental health status | The symptom checklist-90 will be used to evaluate the changes of participants' psychological state through study completion from 10 aspects, including somatization, obsessive-compulsive symptoms, interpersonal sensitivity, depression, anxiety, hostility, terror, paranoia, psychotic and others. | through study completion, an average of 1 year |
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