Pharmacokinetics Clinical Trial
Official title:
Scavenging of Endogenous Reactive Carbonyl Species by Apple Polyphenols in Healthy Human Subjects
This is an interventional study to investigate formation and pharmacokinetics of reactive carbonyl species adducts of apple polyphenols in human after a single dose of apple consumption.
A crossover design was used. Twelve healthy volunteers were recruited and asked to avoid the
consumption of any apple products starting 1 week before intervention and continuing
throughout the entire study for a total of 3 weeks.
On week 2, each of six participants received 600 g apple blends (seeds removal) in a single
dose, and afterwards, urine and blood samples at different timepoints over 24 h, and fecal
sample at different timepoints over 48 h were collected. Meanwhile, other six participants
received breakfast (without any apple products) only, and urine and blood samples at
different timepoints over 24 h, and fecal sample at different timepoints over 48 h were
collected.
On the contrary, on week 3, six participants who received apple blends on week 2 received
breakfast only, and six participants who were used as control on week 2 received apple
blends. And urine and blood samples at different timepoints over 24 h, and fecal sample at
different timepoints over 48 h for both groups were collected.
Samples will be analyzed by LC-MS/MS. Pharmacokinetics of conjugates will be investigated.
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